Homo sapiens Gene: OSBP
Summary
InnateDB Gene IDBG-48409.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol OSBP
Gene Name oxysterol binding protein
Synonyms OSBP1
Species Homo sapiens
Ensembl Gene ENSG00000110048
Encoded Proteins
oxysterol binding protein
oxysterol binding protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Oxysterol binding protein is an intracellular protein that is believed to transport sterols from lysosomes to the nucleus where the sterol down-regulates the genes for the LDL receptor, HMG-CoA reductase, and HMG synthetase [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:59574398-59616144
Strand Reverse strand
Band q12.1
Transcripts
ENST00000263847 ENSP00000263847
ENST00000525357 ENSP00000432399
ENST00000528903
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
Experimentally validated
Total 31 [view]
Protein-Protein 30 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008142 oxysterol binding
Biological Process
GO:0006869 lipid transport
Cellular Component
GO:0000139 Golgi membrane
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0030054 cell junction
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Sphingolipid de novo biosynthesis pathway
Sphingolipid metabolism pathway
Metabolism of lipids and lipoproteins pathway
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P22059
TrEMBL B4DR25
UniProt Splice Variant
Entrez Gene 5007
UniGene Hs.597091 Hs.713727 Hs.713814
RefSeq NM_002556
HUGO HGNC:8503
OMIM 167040
CCDS CCDS7974
HPRD
IMGT
EMBL AF185696 AF185697 AF185698 AF185699 AF185700 AF185701 AF185702 AF185703 AF185704 AF185705 AK299071 BC011581 BC063121 M86917
GenPept AAA59973 AAG17011 AAG28373 AAH11581 AAH63121 BAG61137
RNA Seq Atlas 5007