Homo sapiens Gene: COX7A2L | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-48417.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | COX7A2L | ||||||||||||||||||
Gene Name | cytochrome c oxidase subunit VIIa polypeptide 2 like | ||||||||||||||||||
Synonyms | COX7AR; COX7RP; EB1; SIG81 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000115944 | ||||||||||||||||||
Encoded Proteins |
cytochrome c oxidase subunit VIIa polypeptide 2 like
cytochrome c oxidase subunit VIIa polypeptide 2 like
cytochrome c oxidase subunit VIIa polypeptide 2 like
cytochrome c oxidase subunit VIIa polypeptide 2 like
cytochrome c oxidase subunit VIIa polypeptide 2 like
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
Cytochrome c oxidase (COX), the terminal component of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. This component is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may function in the regulation and assembly of the complex. This nuclear gene encodes a protein similar to polypeptides 1 and 2 of subunit VIIa in the C-terminal region, and also highly similar to the mouse Sig81 protein sequence. This gene is expressed in all tissues, and upregulated in a breast cancer cell line after estrogen treatment. It is possible that this gene represents a regulatory subunit of COX and mediates the higher level of energy production in target cells by estrogen. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 2:42333546-42425088 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | p21 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
No orthologs found for this gene | |||||||||||||||||||
Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME |
Respiratory electron transport pathway
Transmembrane transport of small molecules pathway
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
Orphan transporters pathway
The citric acid (TCA) cycle and respiratory electron transport pathway
Metabolism pathway
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KEGG |
Alzheimer's disease pathway
Oxidative phosphorylation pathway
Parkinson's disease pathway
Huntington's disease pathway
Cardiac muscle contraction pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | E5RJZ1 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 9167 | ||||||||||||||||||
UniGene | Hs.339639 Hs.625162 Hs.697553 Hs.726685 Hs.743790 | ||||||||||||||||||
RefSeq | NM_004718 | ||||||||||||||||||
HUGO | HGNC:2289 | ||||||||||||||||||
OMIM | 605771 | ||||||||||||||||||
CCDS | CCDS1808 | ||||||||||||||||||
HPRD | 05774 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC006038 | ||||||||||||||||||
GenPept | |||||||||||||||||||
RNA Seq Atlas | 9167 | ||||||||||||||||||