Version 5.4
Homo sapiens Gene: TRHDE
Summary
InnateDB Gene IDBG-48439.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRHDE
Gene Name thyrotropin-releasing hormone degrading enzyme
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000072657
Encoded Proteins
IDBP-48441
thyrotropin-releasing hormone degrading enzyme
IDBP-603386
thyrotropin-releasing hormone degrading enzyme
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the peptidase M1 family. The encoded protein is an extracellular peptidase that specifically cleaves and inactivates the neuropeptide thyrotropin-releasing hormone.[provided by RefSeq, Dec 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:72087266-72670757
Strand Forward strand
Band q21.1
Transcripts
ENST00000261180 ENSP00000261180
ENST00000548156
ENST00000547300 ENSP00000447822
ENST00000552503
ENST00000549138
ENST00000549401
ENST00000549922
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050663
View Gene Order
ENSBTAG00000018575
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.199814
RefSeq NM_013381
HUGO
OMIM
CCDS CCDS9004
HPRD 09506
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca