Version 5.4
Homo sapiens Gene: SCML2
Summary
InnateDB Gene IDBG-48532.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCML2
Gene Name sex comb on midleg-like 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000102098
Encoded Proteins
IDBP-48534
sex comb on midleg-like 2 (Drosophila)
IDBP-233984
sex comb on midleg-like 2 (Drosophila)
IDBP-363534
sex comb on midleg-like 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Polycomb group proteins. These proteins form the Polycomb repressive complexes which are involved in transcriptional repression. The encoded protein binds histone peptides that are monomethylated at lysine residues and may be involved in regulating homeotic gene expression during development. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome X:18239314-18354727
Strand Reverse strand
Band p22.13
Transcripts
ENST00000251900 ENSP00000251900
ENST00000398048 ENSP00000381126
ENST00000420857 ENSP00000407315
ENST00000491988
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 22 experimentally validated interaction(s) in this database.
Experimentally validated
Total 22 [view]
Protein-Protein 19 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0009653 anatomical structure morphogenesis
Cellular Component
GO:0005634 nucleus
GO:0031519 PcG protein complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.495774 Hs.619095
RefSeq NM_006089 XM_006724458
HUGO
OMIM
CCDS CCDS14185
HPRD 02195
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca