Version 5.4
Homo sapiens Gene: RASGRP4
Summary
InnateDB Gene IDBG-48854.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RASGRP4
Gene Name RAS guanyl releasing protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000171777
Encoded Proteins
IDBP-48856
RAS guanyl releasing protein 4
IDBP-601560
RAS guanyl releasing protein 4
IDBP-379316
RAS guanyl releasing protein 4
IDBP-379317
RAS guanyl releasing protein 4
IDBP-762517
IDBP-765240
IDBP-764977
IDBP-762908
IDBP-763675
IDBP-812742
RAS guanyl releasing protein 4
IDBP-812743
RAS guanyl releasing protein 4
IDBP-812746
RAS guanyl releasing protein 4
IDBP-812770
RAS guanyl releasing protein 4
IDBP-812784
RAS guanyl releasing protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the Ras guanyl nucleotide-releasing protein (RasGRP) family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two calcium-binding EF hands. This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell lines was found to be correlated with elevated level of activated RAS protein, and the RAS activation can be greatly enhanced by phorbol ester treatment, which suggested a role of this protein in diacylglycerol regulated cell signaling pathways. Studies of a mast cell leukemia cell line expressing substantial amounts of abnormal transcripts of this gene indicated that this gene may play an important role in the final stages of mast cell development. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38409051-38426305
Strand Reverse strand
Band q13.2
Transcripts
ENST00000293062 ENSP00000293062
ENST00000426920 ENSP00000445966
ENST00000454404 ENSP00000416463
ENST00000433821 ENSP00000411878
ENST00000587753 ENSP00000468483
ENST00000587287
ENST00000589358 ENSP00000465742
ENST00000592322
ENST00000586305 ENSP00000467604
ENST00000589100
ENST00000589474 ENSP00000466928
ENST00000588404
ENST00000587738 ENSP00000465772
ENST00000588708
ENST00000615340
ENST00000614135 ENSP00000479078
ENST00000622174 ENSP00000484345
ENST00000617966 ENSP00000479888
ENST00000615439 ENSP00000479844
ENST00000618320 ENSP00000481053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005088 Ras guanyl-nucleotide exchange factor activity
GO:0005509 calcium ion binding
GO:0019992 diacylglycerol binding
GO:0030742 GTP-dependent protein binding
Biological Process
GO:0007169 transmembrane receptor protein tyrosine kinase signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007264 small GTPase mediated signal transduction
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0008283 cell proliferation
GO:0009991 response to extracellular stimulus
GO:0016049 cell growth
GO:0030099 myeloid cell differentiation
GO:0032320 positive regulation of Ras GTPase activity
GO:0035556 intracellular signal transduction
GO:0046579 positive regulation of Ras protein signal transduction
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030589
View Gene Order
ENSBTAG00000006998
Not yet available
Pathways
NETPATH
REACTOME
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_6802
Innate Immune System pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
ras_pathway
Regulation of Ras family activation
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001146202 NM_001146203 NM_001146204 NM_001146205 NM_001146206 NM_001146207 NM_170604
HUGO
OMIM
CCDS CCDS46068 CCDS54262 CCDS54263 CCDS54264
HPRD
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca