Version 5.4
Homo sapiens Gene: NET1
Summary
InnateDB Gene IDBG-48898.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NET1
Gene Name neuroepithelial cell transforming 1
Synonyms ARHGEF8; NET1A
Species Homo sapiens
Ensembl Gene ENSG00000173848
Encoded Proteins
IDBP-48900
neuroepithelial cell transforming 1
IDBP-48902
neuroepithelial cell transforming 1
IDBP-363375
neuroepithelial cell transforming 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:5412551-5458463
Strand Forward strand
Band p15.1
Transcripts
ENST00000355029 ENSP00000347134
ENST00000380359 ENSP00000369717
ENST00000449083 ENSP00000403101
ENST00000486354
ENST00000465087
ENST00000484741
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0017049 GTP-Rho binding
Biological Process
GO:0001558 regulation of cell growth
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0043065 positive regulation of apoptotic process
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0051451 myoblast migration
GO:0070301 cellular response to hydrogen peroxide
GO:0071479 cellular response to ionizing radiation
GO:0097190 apoptotic signaling pathway
GO:1900026 positive regulation of substrate adhesion-dependent cell spreading
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021215
View Gene Order
ENSBTAG00000007648
Not yet available
Pathways
NETPATH
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_11061
Signalling by NGF pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
KEGG
INOH
PID NCI
rhoa_reg_pathway
Regulation of RhoA activity
Cross-References
SwissProt Q7Z628
TrEMBL B4E1Y1 Q5SQI5 Q5SQI6 Q5SQI7
UniProt Splice Variant
Entrez Gene 10276
UniGene Hs.25155 Hs.713138
RefSeq NM_001047160 NM_005863
HUGO HGNC:14592
OMIM 606450
CCDS CCDS41483 CCDS7067
HPRD
IMGT
EMBL AJ010046 AK299335 AK304028 AK315566 AL732437 BC010285 BC053553 CH471072 S82401 U02081
GenPept AAB08847 AAB37683 AAH10285 AAH53553 BAG37941 BAG61338 BAG64943 CAA08974 EAW86445 EAW86446
RNA Seq Atlas 10276

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca