Version 5.4
Homo sapiens Gene: IK
Summary
InnateDB Gene IDBG-49207.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IK
Gene Name IK cytokine, down-regulator of HLA II
Synonyms CSA2; RED
Species Homo sapiens
Ensembl Gene ENSG00000113141
Encoded Proteins
IDBP-378535
IK cytokine, down-regulator of HLA II
IDBP-473343
IK cytokine, down-regulator of HLA II
IDBP-475462
IK cytokine, down-regulator of HLA II
IDBP-475501
IK cytokine, down-regulator of HLA II
IDBP-475450
IK cytokine, down-regulator of HLA II
IDBP-478783
IK cytokine, down-regulator of HLA II
IDBP-812027
IK cytokine, down-regulator of HLA II
IDBP-812031
IK cytokine, down-regulator of HLA II
IDBP-812042
IK cytokine, down-regulator of HLA II
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene was identified by its RED repeat, a stretch of repeated arginine, glutamic acid and aspartic acid residues. The protein localizes to discrete dots within the nucleus, excluding the nucleolus. Its function is unknown. This gene maps to chromosome 5; however, a pseudogene may exist on chromosome 2. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:140647058-140662479
Strand Forward strand
Band q31.3
Transcripts
ENST00000417647 ENSP00000396301
ENST00000513256 ENSP00000425564
ENST00000503332 ENSP00000421930
ENST00000507593 ENSP00000424622
ENST00000508301 ENSP00000422641
ENST00000523672
ENST00000502899 ENSP00000426764
ENST00000512827
ENST00000515015
ENST00000515592
ENST00000610522 ENSP00000481369
ENST00000613660 ENSP00000484405
ENST00000620556 ENSP00000480993
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 88 [view]
Protein-Protein 88 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042802 identical protein binding
Biological Process
GO:0006955 immune response
GO:0007267 cell-cell signaling
Cellular Component
GO:0005615 extracellular space
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024474
View Gene Order
ENSBTAG00000015034
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.421245
RefSeq NM_006083
HUGO
OMIM
CCDS CCDS47280
HPRD 02771
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca