InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SYT1

Summary

InnateDB Gene

IDBG-49321.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SYT1

Gene Name

synaptotagmin I

Synonyms

P65; SVP65; SYT

Species

Homo sapiens

Ensembl Gene

ENSG00000067715

Encoded Proteins

IDBP-49323

synaptotagmin I

IDBP-244023

synaptotagmin I

IDBP-380571

synaptotagmin I

IDBP-380572

synaptotagmin I

IDBP-603879

synaptotagmin I

IDBP-588635

synaptotagmin I

IDBP-595570

synaptotagmin I

IDBP-590880

synaptotagmin I

IDBP-589596

synaptotagmin I

IDBP-589693

synaptotagmin I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The synaptotagmins are integral membrane proteins of synaptic vesicles thought to serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Calcium binding to synaptotagmin-1 participates in triggering neurotransmitter release at the synapse (Fernandez-Chacon et al., 2001 [PubMed 11242035]).[supplied by OMIM, Jul 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:78863993-79452008

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000261205	ENSP00000261205
ENST00000393240	ENSP00000376932
ENST00000457153	ENSP00000391056
ENST00000446242	ENSP00000401559
ENST00000552074	ENSP00000447035
ENST00000549454
ENST00000547046	ENSP00000448964
ENST00000549671	ENSP00000450321
ENST00000551304	ENSP00000447656
ENST00000552744	ENSP00000447575
ENST00000552624	ENSP00000448861
ENST00000549559

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.

Experimentally validated
Total	28 [view]
Protein-Protein	28 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	6 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000149	SNARE binding
GO:0001786	phosphatidylserine binding
GO:0005215	transporter activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0005543	phospholipid binding
GO:0005544	calcium-dependent phospholipid binding
GO:0005545	1-phosphatidylinositol binding
GO:0005546	phosphatidylinositol-4,5-bisphosphate binding
GO:0008022	protein C-terminus binding
GO:0017075	syntaxin-1 binding
GO:0019905	syntaxin binding
GO:0030276	clathrin binding
GO:0042802	identical protein binding
GO:0048306	calcium-dependent protein binding
GO:0050750	low-density lipoprotein particle receptor binding

Biological Process

GO:0005513	detection of calcium ion
GO:0006810	transport
GO:0007268	synaptic transmission
GO:0007269	neurotransmitter secretion
GO:0014047	glutamate secretion
GO:0016079	synaptic vesicle exocytosis
GO:0017157	regulation of exocytosis
GO:0017158	regulation of calcium ion-dependent exocytosis
GO:0031340	positive regulation of vesicle fusion
GO:0045956	positive regulation of calcium ion-dependent exocytosis
GO:0048278	vesicle docking
GO:0051260	protein homooligomerization
GO:0051592	response to calcium ion

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0008021	synaptic vesicle
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0030141	secretory granule
GO:0030666	endocytic vesicle membrane
GO:0030672	synaptic vesicle membrane
GO:0031045	dense core granule
GO:0031201	SNARE complex
GO:0042584	chromaffin granule membrane
GO:0042734	presynaptic membrane
GO:0043005	neuron projection
GO:0043229	intracellular organelle
GO:0060076	excitatory synapse
GO:0060201	clathrin-sculpted acetylcholine transport vesicle membrane
GO:0060203	clathrin-sculpted glutamate transport vesicle membrane
GO:0061202	clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane
GO:0070083	clathrin-sculpted monoamine transport vesicle membrane