InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CYB5A

Summary

InnateDB Gene

IDBG-4942.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CYB5A

Gene Name

cytochrome b5 type A (microsomal)

Synonyms

CYB5; MCB5

Species

Homo sapiens

Ensembl Gene

ENSG00000166347

Encoded Proteins

IDBP-4944

cytochrome b5 type A (microsomal)

IDBP-4946

cytochrome b5 type A (microsomal)

IDBP-234300

cytochrome b5 type A (microsomal)

IDBP-597075

cytochrome b5 type A (microsomal)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a membrane-bound cytochrome that reduces ferric hemoglobin (methemoglobin) to ferrous hemoglobin, which is required for stearyl-CoA-desaturase activity. Defects in this gene are a cause of type IV hereditary methemoglobinemia. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:74250847-74292016

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000340533	ENSP00000341625
ENST00000299438	ENSP00000299438
ENST00000397914	ENSP00000381011
ENST00000494131	ENSP00000436461
ENST00000583418
ENST00000580678
ENST00000579064

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	16 [view]
Protein-Protein	12 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004033	aldo-keto reductase (NADP) activity
GO:0004129	cytochrome-c oxidase activity
GO:0019899	enzyme binding
GO:0020037	heme binding
GO:0046872	metal ion binding

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0019852	L-ascorbic acid metabolic process
GO:0044281	small molecule metabolic process
GO:0046686	response to cadmium ion
GO:0055114	oxidation-reduction process
GO:1902600	hydrogen ion transmembrane transport

Cellular Component

GO:0005739	mitochondrion
GO:0005741	mitochondrial outer membrane
GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0043231	intracellular membrane-bounded organelle
GO:0070062	extracellular vesicular exosome