Version 5.4
Homo sapiens Gene: PPM1B
Summary
InnateDB Gene IDBG-49488.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PPM1B
Gene Name protein phosphatase, Mg2+/Mn2+ dependent, 1B
Synonyms PP2C-beta; PP2C-beta-X; PP2CB; PP2CBETA; PPC2BETAX
Species Homo sapiens
Ensembl Gene ENSG00000138032
Encoded Proteins
IDBP-49490
protein phosphatase, Mg2+/Mn2+ dependent, 1B
IDBP-49498
protein phosphatase, Mg2+/Mn2+ dependent, 1B
IDBP-49502
protein phosphatase, Mg2+/Mn2+ dependent, 1B
IDBP-293723
protein phosphatase, Mg2+/Mn2+ dependent, 1B
IDBP-293716
protein phosphatase, Mg2+/Mn2+ dependent, 1B
IDBP-374314
protein phosphatase, Mg2+/Mn2+ dependent, 1B
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase has been shown to dephosphorylate cyclin-dependent kinases (CDKs), and thus may be involved in cell cycle control. Overexpression of this phosphatase is reported to cause cell-growth arrest or cell death. Alternative splicing results in multiple transcript variants encoding different isoforms. Additional transcript variants have been described, but currently do not represent full-length sequences. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:44167969-44244384
Strand Forward strand
Band p21
Transcripts
ENST00000378551 ENSP00000367813
ENST00000378540
ENST00000282412 ENSP00000282412
ENST00000345249 ENSP00000326089
ENST00000409432 ENSP00000387287
ENST00000409486
ENST00000409473 ENSP00000386982
ENST00000419807 ENSP00000390087
ENST00000459690
ENST00000487286
ENST00000488866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 50 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 50 [view]
Protein-Protein 49 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004721 phosphoprotein phosphatase activity
GO:0004722 protein serine/threonine phosphatase activity
GO:0005515 protein binding
GO:0030145 manganese ion binding
Biological Process
GO:0006470 protein dephosphorylation
GO:0006499 N-terminal protein myristoylation
GO:0019221 cytokine-mediated signaling pathway
GO:0032688 negative regulation of interferon-beta production
GO:0035970 peptidyl-threonine dephosphorylation
GO:0042347 negative regulation of NF-kappaB import into nucleus
GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling
GO:0050687 negative regulation of defense response to virus
Cellular Component
GO:0005829 cytosol
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000061130
View Gene Order
ENSBTAG00000000223
Not yet available
Pathways
NETPATH
REACTOME
REACT_115831
ISG15 antiviral mechanism pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_25229
Interferon Signaling pathway
REACT_6900
Immune System pathway
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.416769 Hs.598334 Hs.614025 Hs.713776
RefSeq NM_001033557 NM_002706 NM_177968 NM_177969
HUGO
OMIM
CCDS CCDS1816 CCDS1817 CCDS1818 CCDS46271
HPRD 04796
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca