InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SMOX

Summary

InnateDB Gene

IDBG-49525.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SMOX

Gene Name

spermine oxidase

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000088826

Encoded Proteins

IDBP-49527

spermine oxidase

IDBP-49529

spermine oxidase

IDBP-49531

spermine oxidase

IDBP-49533

spermine oxidase

IDBP-49535

spermine oxidase

IDBP-364764

spermine oxidase

IDBP-808216

spermine oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Polyamines are ubiquitous polycationic alkylamines which include spermine, spermidine, putrescine, and agmatine. These molecules participate in a broad range of cellular functions which include cell cycle modulation, scavenging reactive oxygen species, and the control of gene expression. These molecules also play important roles in neurotransmission through their regulation of cell-surface receptor activity, involvement in intracellular signalling pathways, and their putative roles as neurotransmitters. This gene encodes an FAD-containing enzyme that catalyzes the oxidation of spermine to spermadine and secondarily produces hydrogen peroxide. Multiple transcript variants encoding different isoenzymes have been identified for this gene, some of which have failed to demonstrate significant oxidase activity on natural polyamine substrates. The characterized isoenzymes have distinctive biochemical characteristics and substrate specificities, suggesting the existence of additional levels of complexity in polyamine catabolism. [provided by RefSeq, Jul 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:4120980-4187747

Strand

Forward strand

Band

p13

Transcripts

ENST00000305958	ENSP00000307252
ENST00000278795	ENSP00000278795
ENST00000339123	ENSP00000344595
ENST00000346595	ENSP00000341775
ENST00000379460	ENSP00000368773
ENST00000457205	ENSP00000407269
ENST00000493223
ENST00000484515
ENST00000494098
ENST00000486998
ENST00000466004
ENST00000621355	ENSP00000478305

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016491	oxidoreductase activity
GO:0046592	polyamine oxidase activity
GO:0052894	norspermine:oxygen oxidoreductase activity
GO:0052895	N1-acetylspermine:oxygen oxidoreductase (N1-acetylspermidine-forming) activity
GO:0052901	spermine:oxygen oxidoreductase (spermidine-forming) activity

Biological Process

GO:0006595	polyamine metabolic process
GO:0006596	polyamine biosynthetic process
GO:0006598	polyamine catabolic process
GO:0006805	xenobiotic metabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046208	spermine catabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027333

View Gene Order

ENSBTAG00000001112

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa00330

Arginine and proline metabolism pathway

hsa00410

beta-Alanine metabolism pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.742079

RefSeq

NM_001270691 NM_175839 NM_175840 NM_175841 NM_175842 XM_006723578

HUGO

OMIM

CCDS

CCDS13075 CCDS13076 CCDS13077 CCDS13078 CCDS74702

HPRD

11587

IMGT

EMBL

GenPept

RNA Seq Atlas