Homo sapiens Gene: PCDHA5 | |||||||||
---|---|---|---|---|---|---|---|---|---|
Summary | |||||||||
InnateDB Gene | IDBG-49588.6 | ||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||
Gene Symbol | PCDHA5 | ||||||||
Gene Name | protocadherin alpha 5 | ||||||||
Synonyms | |||||||||
Species | Homo sapiens | ||||||||
Ensembl Gene | ENSG00000204965 | ||||||||
Encoded Proteins |
protocadherin alpha 5
protocadherin alpha 5
protocadherin alpha 5
protocadherin alpha 5
|
||||||||
Protein Structure | |||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||
Entrez Gene | |||||||||
Summary |
This gene is a member of the protocadherin alpha gene cluster, one of three related gene clusters tandemly linked on chromosome five that demonstrate an unusual genomic organization similar to that of B-cell and T-cell receptor gene clusters. The alpha gene cluster is composed of 15 cadherin superfamily genes related to the mouse CNR genes and consists of 13 highly similar and 2 more distantly related coding sequences. The tandem array of 15 N-terminal exons, or variable exons, are followed by downstream C-terminal exons, or constant exons, which are shared by all genes in the cluster. The large, uninterrupted N-terminal exons each encode six cadherin ectodomains while the C-terminal exons encode the cytoplasmic domain. These neural cadherin-like cell adhesion proteins are integral plasma membrane proteins that most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been observed and additional variants have been suggested but their full-length nature has yet to be determined. [provided by RefSeq, Jul 2008] |
||||||||
Gene Information | |||||||||
Type | Protein coding | ||||||||
Genomic Location | Chromosome 5:140821604-141012344 | ||||||||
Strand | Forward strand | ||||||||
Band | q31.3 | ||||||||
Transcripts |
|
||||||||
Interactions | |||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
||||||||
Gene Ontology | |||||||||
Molecular Function |
|
||||||||
Biological Process |
|
||||||||
Cellular Component |
|
||||||||
Orthologs | |||||||||
No orthologs found for this gene | |||||||||
Cross-References | |||||||||
SwissProt | Q9Y5H7 | ||||||||
TrEMBL | |||||||||
UniProt Splice Variant | |||||||||
Entrez Gene | 56143 | ||||||||
UniGene | |||||||||
RefSeq | NM_018908 NM_031501 NM_018909 NM_031848 NM_031849 | ||||||||
HUGO | HGNC:8671 | ||||||||
OMIM | 606311 | ||||||||
CCDS | CCDS54917 CCDS47281 CCDS47282 | ||||||||
HPRD | |||||||||
IMGT | |||||||||
EMBL | AC005609 AF152313 AF152483 BC033735 | ||||||||
GenPept | AAC34321 AAD43707 AAD43744 AAH33735 | ||||||||
RNA Seq Atlas | 56143 | ||||||||