Homo sapiens Gene: CD200
Summary
InnateDB Gene IDBG-49799.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CD200
Gene Name CD200 molecule
Synonyms MOX1; MOX2; MRC; OX-2
Species Homo sapiens
Ensembl Gene ENSG00000091972
Encoded Proteins
CD200 molecule
CD200 molecule
CD200 molecule
CD200 molecule
CD200 molecule
CD200 molecule
CD200 molecule
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
CD200 is induced by TLR-, NOD2-, and NALP3-mediated pathways, limiting macrophage activation and protecting the host from excessive inflammation.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Cd200-Cd200r1 pathway is an important regulator of antiviral immunity during cytomegalovirus infection that is exploited by murine cytomegalovirus to establish chronicity within mucosal tissue.
Entrez Gene
Summary The protein encoded by this gene is a type-1 membrane glycoprotein, which contains two immunoglobulin domains, and thus belongs to the immunoglobulin superfamily. Studies of the related genes in mouse and rat suggest that this gene may regulate myeloid cell activity and delivers an inhibitory signal for the macrophage lineage in diverse tissues. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:112332347-112362812
Strand Forward strand
Band q13.2
Transcripts
ENST00000383681 ENSP00000373179
ENST00000315711 ENSP00000312766
ENST00000498096 ENSP00000418576
ENST00000473539 ENSP00000420298
ENST00000478595 ENSP00000419816
ENST00000607597 ENSP00000476114
ENST00000606471 ENSP00000475860
ENST00000607516
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 5 [view]
Protein-Protein 2 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0045087 innate immune response (InnateDB)
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
Adaptive Immune System pathway
Immune System pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P41217
TrEMBL F8W7G1 U3KQQ2
UniProt Splice Variant
Entrez Gene 4345
UniGene Hs.594517 Hs.79015
RefSeq NM_001004196 NM_005944 XM_005247482 XM_005247487 XM_005247489 XM_005247490
HUGO HGNC:7203
OMIM 155970
CCDS CCDS33818 CCDS2965
HPRD
IMGT
EMBL AC112487 AF063591 AK074972 AK297194 AY603771 BC022522 BC031103 CH471052 X05323 X05324 X05325 X05326
GenPept AAG43150 AAH22522 AAH31103 AAT37533 BAG52043 BAG59681 CAA28943 EAW79672 EAW79676
RNA Seq Atlas 4345