Version 5.4
Homo sapiens Gene: PREPL
Summary
InnateDB Gene IDBG-49819.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PREPL
Gene Name prolyl endopeptidase-like
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000138078
Encoded Proteins
IDBP-49718
prolyl endopeptidase-like
IDBP-49821
prolyl endopeptidase-like
IDBP-49823
prolyl endopeptidase-like
IDBP-293675
prolyl endopeptidase-like
IDBP-293678
prolyl endopeptidase-like
IDBP-293666
prolyl endopeptidase-like
IDBP-293663
prolyl endopeptidase-like
IDBP-293662
prolyl endopeptidase-like
IDBP-374446
prolyl endopeptidase-like
IDBP-374448
prolyl endopeptidase-like
IDBP-374463
prolyl endopeptidase-like
IDBP-374475
prolyl endopeptidase-like
IDBP-374478
prolyl endopeptidase-like
IDBP-593799
prolyl endopeptidase-like
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene belongs to the prolyl oligopeptidase subfamily of serine peptidases. Mutations in this gene have been associated with hypotonia-cystinuria syndrome, also known as the 2p21 deletion syndrome. Several alternatively spliced transcript variants encoding either the same or different isoforms have been described for this gene.[provided by RefSeq, Jan 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:44316281-44361862
Strand Reverse strand
Band p21
Transcripts
ENST00000378520 ENSP00000367781
ENST00000260648 ENSP00000260648
ENST00000378511 ENSP00000367772
ENST00000409936 ENSP00000386543
ENST00000409272 ENSP00000386909
ENST00000410081 ENSP00000386509
ENST00000409957 ENSP00000387241
ENST00000409411 ENSP00000387095
ENST00000425263 ENSP00000391456
ENST00000426481 ENSP00000409480
ENST00000444696 ENSP00000390618
ENST00000420756 ENSP00000395692
ENST00000438314 ENSP00000395034
ENST00000477410
ENST00000540817
ENST00000541738 ENSP00000439626
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0070008 serine-type exopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005794 Golgi apparatus
GO:0005829 cytosol
GO:0005856 cytoskeleton
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024127
View Gene Order
ENSBTAG00000017429
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.444349 Hs.676222
RefSeq NM_001042385 NM_001042386 NM_001171603 NM_001171606 NM_001171613 NM_001171617 NM_006036
HUGO
OMIM
CCDS CCDS33190 CCDS42675 CCDS42676 CCDS54353
HPRD 17189
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca