Homo sapiens Gene: FBXO27
Summary
InnateDB Gene IDBG-49906.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FBXO27
Gene Name F-box protein 27
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000161243
Encoded Proteins
F-box protein 27
F-box protein 27
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the F-box protein family, such as FBXO27, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:38990714-39032785
Strand Reverse strand
Band q13.2
Transcripts
ENST00000292853 ENSP00000292853
ENST00000509137 ENSP00000437662
ENST00000595166
ENST00000600828 ENSP00000470015
ENST00000593847 ENSP00000471772
ENST00000594770
ENST00000598394 ENSP00000471267
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001948 glycoprotein binding
GO:0005515 protein binding
Biological Process
Cellular Component
GO:0019005 SCF ubiquitin ligase complex
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Pathways
NETPATH
REACTOME
Antigen processing: Ubiquitination & Proteasome degradation pathway
Adaptive Immune System pathway
Immune System pathway
Class I MHC mediated antigen processing & presentation pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 126433
UniGene Hs.187461
RefSeq NM_178820 XM_006723017
HUGO HGNC:18753
OMIM 609099
CCDS CCDS12527
HPRD 16440
IMGT
EMBL
GenPept
RNA Seq Atlas 126433