|Homo sapiens Gene: IL29|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||interleukin 29 (interferon, lambda 1)|
interleukin 29 (interferon, lambda 1)
|Useful resources||Stemformatics EHFPI ImmGen|
IL29 is able to efficiently inhibit Herpes Simplex Virus Type-1 replication in neuronal cells by inducing the expression of TLR as well as activate the TLR-mediated interferon antiviral pathway.
IFNL1 (IL29), IFNL2 and IFNL3 have different effects on Toll-like receptor-related gene expression in HepG2 cells.
IFN-λ1 is able to augment TLR-mediated B cell activation, partially attributed to an upregulation of TLR7 expression
Influenza B virus induces IRF3 activation and IL29 (IFNL1) gene expression without a requirement for viral protein synthesis or replication and DDX58 is the critical pattern recognition receptor needed for IRF3 activation.
This gene encodes a cytokine distantly related to type I interferons and the IL-10 family. This gene, interleukin 28A (IL28A), and interleukin 28B (IL28B) are three closely related cytokine genes that form a cytokine gene cluster on a chromosomal region mapped to 19q13. Expression of the cytokines encoded by the three genes can be induced by viral infection. All three cytokines have been shown to interact with a heterodimeric class II cytokine receptor that consists of interleukin 10 receptor, beta (IL10RB) and interleukin 28 receptor, alpha (IL28RA). [provided by RefSeq, Jul 2008]
|Genomic Location||Chromosome 19:39296325-39298673|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
|No orthologs found for this gene|
Cytokine-cytokine receptor interaction pathway
Jak-STAT signaling pathway pathway
|UniProt Splice Variant|
|EMBL||AC011445 AY129150 AY184372 AY336716 BC074985 BC117482 BC126183 HQ214053|
|GenPept||AAH74985 AAI17483 AAI26184 AAN28265 AAN86125 AAR24511 ADO12077|
|RNA Seq Atlas||282618|