InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INSIG1

Summary

InnateDB Gene

IDBG-50271.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INSIG1

Gene Name

insulin induced gene 1

Synonyms

CL-6; CL6

Species

Homo sapiens

Ensembl Gene

ENSG00000186480

Encoded Proteins

IDBP-50273

insulin induced gene 1

IDBP-50275

insulin induced gene 1

IDBP-50277

insulin induced gene 1

IDBP-387520

insulin induced gene 1

IDBP-482947

insulin induced gene 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 25526307

Upon cytoplasmic DNA stimulation, the endoplasmic reticulum protein AMFR is recruited to and interacts with TMEM173 in an INSIG1-dependent manner.

Entrez Gene

Summary

Oxysterols regulate cholesterol homeostasis through the liver X receptor (LXR)- and sterol regulatory element-binding protein (SREBP)-mediated signaling pathways. This gene is an insulin-induced gene. It encodes an endoplasmic reticulum (ER) membrane protein that plays a critical role in regulating cholesterol concentrations in cells. This protein binds to the sterol-sensing domains of SREBP cleavage-activating protein (SCAP) and HMG CoA reductase, and is essential for the sterol-mediated trafficking of the two proteins. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jun 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 7:155297776-155310235

Strand

Forward strand

Band

q36.3

Transcripts

ENST00000344756	ENSP00000340010
ENST00000340368	ENSP00000344741
ENST00000342407	ENSP00000344035
ENST00000425172	ENSP00000414691
ENST00000476756	ENSP00000420198
ENST00000468307

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 27 experimentally validated interaction(s) in this database.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0006641	triglyceride metabolic process
GO:0006695	cholesterol biosynthetic process
GO:0006991	response to sterol depletion
GO:0008152	metabolic process
GO:0008203	cholesterol metabolic process
GO:0008283	cell proliferation
GO:0010894	negative regulation of steroid biosynthetic process
GO:0016126	sterol biosynthetic process
GO:0032933	SREBP signaling pathway
GO:0042472	inner ear morphogenesis
GO:0042474	middle ear morphogenesis
GO:0044281	small molecule metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0045599	negative regulation of fat cell differentiation
GO:0045717	negative regulation of fatty acid biosynthetic process
GO:0060021	palate development
GO:0060363	cranial suture morphogenesis
GO:1901303	negative regulation of cargo loading into COPII-coated vesicle

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0032937	SREBP-SCAP-Insig complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000045294

View Gene Order

ENSBTAG00000001592

Not yet available

Pathways

NETPATH

REACTOME

REACT_147797

Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.520819

RefSeq

NM_005542 NM_198336 NM_198337

HUGO

OMIM

CCDS

CCDS5938 CCDS5939

HPRD

03633

IMGT

EMBL

GenPept

RNA Seq Atlas