InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC23A2

Summary

InnateDB Gene

IDBG-50310.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC23A2

Gene Name

solute carrier family 23 (nucleobase transporters), member 2

Synonyms

NBTL1; SLC23A1; SVCT2; YSPL2

Species

Homo sapiens

Ensembl Gene

ENSG00000089057

Encoded Proteins

IDBP-50312

solute carrier family 23 (nucleobase transporters), member 2

IDBP-50314

solute carrier family 23 (nucleobase transporters), member 2

IDBP-365008

solute carrier family 23 (nucleobase transporters), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The absorption of vitamin C into the body and its distribution to organs requires two sodium-dependent vitamin C transporters. This gene encodes one of the two required transporters and the encoded protein accounts for tissue-specific uptake of vitamin C. Previously, this gene had an official symbol of SLC23A1. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:4852356-5010293

Strand

Reverse strand

Band

p13

Transcripts

ENST00000379333	ENSP00000368637
ENST00000338244	ENSP00000344322
ENST00000423430	ENSP00000396364
ENST00000468355
ENST00000496331

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005215	transporter activity
GO:0008520	L-ascorbate:sodium symporter activity
GO:0008523	sodium-dependent multivitamin transmembrane transporter activity
GO:0015205	nucleobase transmembrane transporter activity
GO:0015229	L-ascorbic acid transporter activity
GO:0070890	sodium-dependent L-ascorbate transmembrane transporter activity

Biological Process

GO:0006139	nucleobase-containing compound metabolic process
GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0006810	transport
GO:0006814	sodium ion transport
GO:0006979	response to oxidative stress
GO:0015851	nucleobase transport
GO:0015882	L-ascorbic acid transport
GO:0015993	molecular hydrogen transport
GO:0019852	L-ascorbic acid metabolic process
GO:0035461	vitamin transmembrane transport
GO:0044281	small molecule metabolic process
GO:0055085	transmembrane transport
GO:0070904	transepithelial L-ascorbic acid transport

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009925	basal plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0016323	basolateral plasma membrane
GO:0016324	apical plasma membrane