Version 5.4
Homo sapiens Gene: EN2
Summary
InnateDB Gene IDBG-50344.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EN2
Gene Name engrailed homeobox 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164778
Encoded Proteins
IDBP-50346
engrailed homeobox 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the 'engrailed' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Homeobox-containing genes are thought to have a role in controlling development. In Drosophila, the \'engrailed\' (en) gene plays an important role during development in segmentation, where it is required for the formation of posterior compartments. Different mutations in the mouse homologs, En1 and En2, produced different developmental defects that frequently are lethal. The human engrailed homologs 1 and 2 encode homeodomain-containing proteins and have been implicated in the control of pattern formation during development of the central nervous system. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:155458129-155464831
Strand Forward strand
Band q36.3
Transcripts
ENST00000297375 ENSP00000297375
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0043565 sequence-specific DNA binding
Biological Process
GO:0007275 multicellular organismal development
GO:0030182 neuron differentiation
GO:0030901 midbrain development
GO:0030902 hindbrain development
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048666 neuron development
Cellular Component
GO:0005634 nucleus
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000039095
View Gene Order
ENSBTAG00000018917
Not yet available
Cross-References
SwissProt P19622
TrEMBL
UniProt Splice Variant
Entrez Gene 2020
UniGene Hs.134989
RefSeq NM_001427
HUGO HGNC:3343
OMIM 131310
CCDS CCDS5940
HPRD
IMGT
EMBL AC008060 BC104970 BC104972 CH236954 J03066 L12700 L12701
GenPept AAA53504 AAF68670 AAI04971 AAI04973 AAQ96875 EAL23909
RNA Seq Atlas 2020

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca