Version 5.4
Homo sapiens Gene: RAB5C
Summary
InnateDB Gene IDBG-50350.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB5C
Gene Name RAB5C, member RAS oncogene family
Synonyms L1880; RAB5CL; RAB5L; RABL
Species Homo sapiens
Ensembl Gene ENSG00000108774
Encoded Proteins
IDBP-50352
RAB5C, member RAS oncogene family
IDBP-242759
RAB5C, member RAS oncogene family
IDBP-592647
RAB5C, member RAS oncogene family
IDBP-759270
IDBP-585367
RAB5C, member RAS oncogene family
IDBP-597050
RAB5C, member RAS oncogene family
IDBP-595842
RAB5C, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Members of the Rab protein family are small GTPases of the Ras superfamily that are thought to ensure fidelity in the process of docking and/or fusion of vesicles with their correct acceptor compartment (Han et al., 1996 [PubMed 8646882]).[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42124976-42155044
Strand Reverse strand
Band q21.2
Transcripts
ENST00000346213 ENSP00000345689
ENST00000393860 ENSP00000377440
ENST00000547517 ENSP00000447053
ENST00000551338 ENSP00000467144
ENST00000552162 ENSP00000449612
ENST00000546881
ENST00000550504 ENSP00000449777
ENST00000550406 ENSP00000448314
ENST00000550013
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 26 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019003 GDP binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006886 intracellular protein transport
GO:0006913 nucleocytoplasmic transport
GO:0007032 endosome organization
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0015031 protein transport
GO:0030100 regulation of endocytosis
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005811 lipid particle
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030139 endocytic vesicle
GO:0031901 early endosome membrane
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000019173
View Gene Order
ENSBTAG00000006982
Not yet available
Pathways
NETPATH
REACTOME
REACT_19400
Golgi Associated Vesicle Biogenesis pathway
REACT_19187
Clathrin derived vesicle budding pathway
REACT_11235
trans-Golgi Network Vesicle Budding pathway
REACT_11123
Membrane Trafficking pathway
KEGG
hsa04144
Endocytosis pathway
hsa04962
Vasopressin-regulated water reabsorption pathway
hsa05146
Amoebiasis pathway
hsa04145
Phagosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.650382 Hs.718963
RefSeq NM_001252039 NM_004583 NM_201434
HUGO
OMIM
CCDS CCDS11419 CCDS58551
HPRD 04947
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca