Version 5.4
Homo sapiens Gene: PIGF
Summary
InnateDB Gene IDBG-50448.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PIGF
Gene Name phosphatidylinositol glycan anchor biosynthesis, class F
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000151665
Encoded Proteins
IDBP-50452
phosphatidylinositol glycan anchor biosynthesis, class F
IDBP-50454
phosphatidylinositol glycan anchor biosynthesis, class F
IDBP-374630
phosphatidylinositol glycan anchor biosynthesis, class F
IDBP-374631
phosphatidylinositol glycan anchor biosynthesis, class F
IDBP-482049
phosphatidylinositol glycan anchor biosynthesis, class F
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:46580937-46617119
Strand Reverse strand
Band p21
Transcripts
ENST00000306465 ENSP00000302663
ENST00000281382 ENSP00000281382
ENST00000420164 ENSP00000410361
ENST00000412717 ENSP00000413202
ENST00000482786
ENST00000495933
ENST00000474980 ENSP00000429355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 0
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004307 ethanolaminephosphotransferase activity
Biological Process
GO:0006501 C-terminal protein lipidation
GO:0006506 GPI anchor biosynthetic process
GO:0016254 preassembly of GPI anchor in ER membrane
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024145
View Gene Order
ENSBTAG00000015719
Not yet available
Pathways
NETPATH
REACTOME
REACT_952
Synthesis of glycosylphosphatidylinositol (GPI) pathway
REACT_1853
Post-translational modification: synthesis of GPI-anchored proteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_17015
Metabolism of proteins pathway
KEGG
hsa00563
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL E5RIN5 F8WEN5
UniProt Splice Variant
Entrez Gene 5281
UniGene Hs.468415
RefSeq NM_002643 NM_173074
HUGO HGNC:8962
OMIM 600153
CCDS CCDS1827 CCDS1828
HPRD 02539
IMGT
EMBL AC018682
GenPept
RNA Seq Atlas 5281

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca