InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STAT5A

Summary

InnateDB Gene

IDBG-50625.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAT5A

Gene Name

signal transducer and activator of transcription 5A

Synonyms

MGF; STAT5

Species

Homo sapiens

Ensembl Gene

ENSG00000126561

Encoded Proteins

IDBP-50627

signal transducer and activator of transcription 5A

IDBP-378688

signal transducer and activator of transcription 5A

IDBP-599160

signal transducer and activator of transcription 5A

IDBP-764915

IDBP-757919

IDBP-757755

IDBP-762890

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 9398404

IL-2 and IL-7 induced heterodimerization of STAT5 isoforms in human peripheral blood T lymphoblast

Entrez Gene

Summary

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Dec 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:42287547-42311943

Strand

Forward strand

Band

q21.2

Transcripts

ENST00000345506	ENSP00000341208
ENST00000444283	ENSP00000407327
ENST00000469124
ENST00000478897
ENST00000479417
ENST00000468096
ENST00000546010	ENSP00000443107
ENST00000591556
ENST00000587646	ENSP00000466320
ENST00000590726	ENSP00000464730
ENST00000588868	ENSP00000465437
ENST00000590949	ENSP00000468749

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 123 experimentally validated interaction(s) in this database.

Experimentally validated
Total	123 [view]
Protein-Protein	94 [view]
Protein-DNA	29 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0004871	signal transducer activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0019903	protein phosphatase binding

Biological Process

GO:0000255	allantoin metabolic process
GO:0001553	luteinization
GO:0001779	natural killer cell differentiation
GO:0006101	citrate metabolic process
GO:0006103	2-oxoglutarate metabolic process
GO:0006105	succinate metabolic process
GO:0006107	oxaloacetate metabolic process
GO:0006351	transcription, DNA-templated
GO:0006355	regulation of transcription, DNA-templated
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0006549	isoleucine metabolic process
GO:0006573	valine metabolic process
GO:0006600	creatine metabolic process
GO:0006631	fatty acid metabolic process
GO:0007165	signal transduction
GO:0007259	JAK-STAT cascade
GO:0007565	female pregnancy
GO:0007595	lactation
GO:0008284	positive regulation of cell proliferation
GO:0018108	peptidyl-tyrosine phosphorylation
GO:0019218	regulation of steroid metabolic process
GO:0019221	cytokine-mediated signaling pathway
GO:0019530	taurine metabolic process
GO:0019915	lipid storage
GO:0030155	regulation of cell adhesion
GO:0030856	regulation of epithelial cell differentiation
GO:0030879	mammary gland development
GO:0032825	positive regulation of natural killer cell differentiation
GO:0033026	negative regulation of mast cell apoptotic process
GO:0033077	T cell differentiation in thymus
GO:0038161	prolactin signaling pathway
GO:0040014	regulation of multicellular organism growth
GO:0040018	positive regulation of multicellular organism growth
GO:0042104	positive regulation of activated T cell proliferation
GO:0043029	T cell homeostasis
GO:0043066	negative regulation of apoptotic process
GO:0043434	response to peptide hormone
GO:0045086	positive regulation of interleukin-2 biosynthetic process
GO:0045087	innate immune response (InnateDB)
GO:0045579	positive regulation of B cell differentiation
GO:0045588	positive regulation of gamma-delta T cell differentiation
GO:0045621	positive regulation of lymphocyte differentiation
GO:0045647	negative regulation of erythrocyte differentiation
GO:0045931	positive regulation of mitotic cell cycle
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0045954	positive regulation of natural killer cell mediated cytotoxicity
GO:0046449	creatinine metabolic process
GO:0046543	development of secondary female sexual characteristics
GO:0046544	development of secondary male sexual characteristics
GO:0048541	Peyer's patch development
GO:0050729	positive regulation of inflammatory response
GO:0060376	positive regulation of mast cell differentiation
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060740	prostate gland epithelium morphogenesis
GO:0060742	epithelial cell differentiation involved in prostate gland development
GO:0061180	mammary gland epithelium development
GO:0070668	positive regulation of mast cell proliferation
GO:0097011	cellular response to granulocyte macrophage colony-stimulating factor stimulus