Version 5.4
Homo sapiens Gene: EIF1AX
Summary
InnateDB Gene IDBG-50658.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF1AX
Gene Name eukaryotic translation initiation factor 1A, X-linked
Synonyms eIF-1A; eIF-4C; EIF1A; EIF1AP1; EIF4C
Species Homo sapiens
Ensembl Gene ENSG00000173674
Encoded Proteins
IDBP-50660
eukaryotic translation initiation factor 1A, X-linked
IDBP-50662
eukaryotic translation initiation factor 1A, X-linked
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5' end of capped RNA. [provided by RefSeq, Jul 2008]
This gene encodes an essential eukaryotic translation initiation factor. The protein is required for the binding of the 43S complex (a 40S subunit, eIF2/GTP/Met-tRNAi and eIF3) to the 5\' end of capped RNA. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome X:20124518-20141844
Strand Reverse strand
Band p22.12
Transcripts
ENST00000379607 ENSP00000368927
ENST00000379593 ENSP00000368912
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.
Experimentally validated
Total 17 [view]
Protein-Protein 16 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0003743 translation initiation factor activity
GO:0008135 translation factor activity, nucleic acid binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0006412 translation
GO:0006413 translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt P47813
TrEMBL X6RAC9
UniProt Splice Variant
Entrez Gene 1964
UniGene Hs.522590 Hs.602028 Hs.602097 Hs.605331 Hs.606774 Hs.653506 Hs.737196
RefSeq NM_001412
HUGO HGNC:3250
OMIM 300186
CCDS CCDS14196
HPRD
IMGT
EMBL AK312320 AL732366 BC000793 BC067851 BT007064 L18960
GenPept AAA19812 AAH00793 AAH67851 AAP35727 BAG35242 CAI40550 CAI40551
RNA Seq Atlas 1964

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca