Version 5.4
Homo sapiens Gene: STAT3
Summary
InnateDB Gene IDBG-50702.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STAT3
Gene Name signal transducer and activator of transcription 3 (acute-phase response factor)
Synonyms ADMIO; APRF; HIES
Species Homo sapiens
Ensembl Gene ENSG00000168610
Encoded Proteins
IDBP-50704
signal transducer and activator of transcription 3 (acute-phase response factor)
IDBP-50712
signal transducer and activator of transcription 3 (acute-phase response factor)
IDBP-295195
signal transducer and activator of transcription 3 (acute-phase response factor)
IDBP-760155
IDBP-763056
IDBP-763010
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 17971840
STAT3 is a transcription factor that mediates interleukin-10 (IL-10) cytokine signalling.
PMID 19667404
STAT3 and SRC have a role in the immunoregulation of dendritic cells (DCs) where apoptotic cells-induced inhibition of dendritic cells (DCs) requires MerTK-dependent activation of SRC and STAT3.
PMID 20040863
STAT3 mediates mucosa-protective and anti-inflammatory functions in epithelial and myeloid cells and promotes inflammation in T cells.
PMID 20493732
STAT3 binds to multiple genes involved in Th17 cell differentiation, cell activation, proliferation, and survival, regulating both expression, epigenetic modifications, and targets the T cell function in inflammation and homeostasis.
PMID 20581311
STAT3 is an essential mediator of emergency granulopoiesis via its regulation of transcription factors CEBPA and CEBPB that direct granulocyte colony-stimulating factor (G-CSF)-responsive myeloid progenitor expansion.
PMID 21810606
STAT3 is a negative regulator of type I IFN-mediated anti-viral responses. (Demonstrated in mouse)
PMID 25510212
In alveolar epithelium, IL22 upregulates DEFB4A gene expression via STAT3.
PMID 26535690
MIR29A inhibits IL10-induced cytokine release by targeting JAK-STAT3 in monocytes during sepsis.
InnateDB Annotation from Orthologs
Summary
PMID 21810606
[Mus musculus] Stat3 is a negative regulator of type I IFN-mediated anti-viral responses.
PMID 23460517
[Mus musculus] STAT3 mediates protein transport and secretion in hepatocytes during the acute phase of pneumonia.
PMID 24412612
[Mus musculus] Stat3 mediates protection against intestinal infection by inducing innate lymphoid cell derived-Il22.
PMID 25692402
[Mus musculus] Stat3 is required for maximal Osm-induced lung Cxcl5 expression and subsequent neutrophil recruitment during bacterial pneumonia.
Entrez Gene
Summary The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated through phosphorylation in response to various cytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This protein mediates the expression of a variety of genes in response to cell stimuli, and thus plays a key role in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has been shown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor of this protein. Three alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42313324-42388568
Strand Reverse strand
Band q21.2
Transcripts
ENST00000264657 ENSP00000264657
ENST00000389272 ENSP00000373923
ENST00000404395 ENSP00000384943
ENST00000462286
ENST00000491272
ENST00000462269
ENST00000471989
ENST00000498330
ENST00000478276
ENST00000590776
ENST00000588969 ENSP00000467985
ENST00000585360
ENST00000585517 ENSP00000467000
ENST00000588065 ENSP00000467173
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 340 experimentally validated interaction(s) in this database.
They are also associated with 144 interaction(s) predicted by orthology.
Experimentally validated
Total 340 [view]
Protein-Protein 285 [view]
Protein-DNA 53 [view]
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 144 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001659 temperature homeostasis
GO:0001754 eye photoreceptor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0006928 cellular component movement
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0007399 nervous system development
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0016032 viral process
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell maintenance
GO:0019953 sexual reproduction
GO:0030522 intracellular receptor signaling pathway
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0043434 response to peptide hormone
GO:0045087 innate immune response (InnateDB)
GO:0045471 response to ethanol
GO:0045747 positive regulation of Notch signaling pathway
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0048708 astrocyte differentiation
GO:0060019 radial glial cell differentiation
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 negative regulation of cell death
GO:0070102 interleukin-6-mediated signaling pathway
GO:2001223 negative regulation of neuron migration
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005743 mitochondrial inner membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000004040
View Gene Order
ENSBTAG00000021523
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
NetPath_3
Notch pathway
NetPath_4
EGFR1 pathway
NetPath_6
KitReceptor pathway
NetPath_12
BCR pathway
NetPath_13
IL1 pathway
NetPath_14
IL2 pathway
NetPath_15
IL3 pathway
NetPath_16
IL4 pathway
NetPath_17
IL5 pathway
NetPath_18
IL6 pathway
NetPath_19
IL-7 pathway
NetPath_20
IL9 pathway
NetPath_22
Leptin pathway
NetPath_23
TSH pathway
NetPath_24
TSLP pathway
NetPath_56
Prolactin pathway
NetPath_147
IL11 pathway
NetPath_114
Oncostatin_M pathway
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_27307
Interleukin-6 signaling pathway
REACT_12049
Signalling to STAT3 pathway
REACT_111040
Signaling by SCF-KIT pathway
REACT_17025
Downstream signal transduction pathway
REACT_16888
Signaling by PDGF pathway
REACT_121141
Signaling by FGFR1 fusion mutants pathway
REACT_121398
Signaling by FGFR mutants pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_120956
Cellular responses to stress pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_200812
Transcriptional regulation of pluripotent stem cells pathway
REACT_200759
POU5F1 (OCT4), SOX2, NANOG activate genes related to proliferation pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_120999
Signaling by FGFR1 mutants pathway
REACT_111102
Signal Transduction pathway
REACT_6900
Immune System pathway
REACT_169274
Cellular Senescence pathway
REACT_22232
Signaling by Interleukins pathway
REACT_12056
NGF signalling via TRKA from the plasma membrane pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_116125
Disease pathway
REACT_169118
Signaling by Leptin pathway
KEGG
hsa05221
Acute myeloid leukemia pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
hsa05212
Pancreatic cancer pathway
hsa04062
Chemokine signaling pathway pathway
hsa05200
Pathways in cancer pathway
hsa05145
Toxoplasmosis pathway
hsa05160
Hepatitis C pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
EPO signaling pathway pathway
INOH website
IL-6 signaling pathway
INOH website
LIF signaling pathway
INOH website
TPO signaling pathway
INOH website
IL-23 signaling pathway
INOH website
IFN alpha signaling pathway
INOH website
IL-10 signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
il2_1pathway
IL2-mediated signaling events
il27pathway
IL27-mediated signaling events
il12_2pathway
IL12-mediated signaling events
ptp1bpathway
Signaling events mediated by PTP1B
erbb1_downstream_pathway
ErbB1 downstream signaling
il12_stat4pathway
IL12 signaling mediated by STAT4
hdac_classi_pathway
Signaling events mediated by HDAC Class I
hes_heypathway
Notch-mediated HES/HEY network
trkrpathway
Neurotrophic factor-mediated Trk receptor signaling
rac1_pathway
RAC1 signaling pathway
fgf_pathway
FGF signaling pathway
kitpathway
Signaling events mediated by Stem cell factor receptor (c-Kit)
tcptp_pathway
Signaling events mediated by TCPTP
il23pathway
IL23-mediated signaling events
erbb2erbb3pathway
ErbB2/ErbB3 signaling events
pdgfrbpathway
PDGFR-beta signaling pathway
il6_7pathway
IL6-mediated signaling events
ifngpathway
IFN-gamma pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.463059
RefSeq NM_003150 NM_139276 NM_213662 XM_005257616 XM_005257617 XM_005257618
HUGO
OMIM
CCDS CCDS32656 CCDS32657 CCDS59288
HPRD 00026
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca