InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PCNA

Summary

InnateDB Gene

IDBG-50801.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PCNA

Gene Name

proliferating cell nuclear antigen

Synonyms

ATLD2

Species

Homo sapiens

Ensembl Gene

ENSG00000132646

Encoded Proteins

IDBP-50803

proliferating cell nuclear antigen

IDBP-50805

proliferating cell nuclear antigen

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is found in the nucleus and is a cofactor of DNA polymerase delta. The encoded protein acts as a homotrimer and helps increase the processivity of leading strand synthesis during DNA replication. In response to DNA damage, this protein is ubiquitinated and is involved in the RAD6-dependent DNA repair pathway. Two transcript variants encoding the same protein have been found for this gene. Pseudogenes of this gene have been described on chromosome 4 and on the X chromosome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:5114953-5126626

Strand

Reverse strand

Band

p12.3

Transcripts

ENST00000379160	ENSP00000368458
ENST00000379143	ENSP00000368438

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 350 experimentally validated interaction(s) in this database.

Experimentally validated
Total	350 [view]
Protein-Protein	344 [view]
Protein-DNA	5 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000701	purine-specific mismatch base pair DNA N-glycosylase activity
GO:0003677	DNA binding
GO:0005515	protein binding
GO:0030337	DNA polymerase processivity factor activity
GO:0030971	receptor tyrosine kinase binding
GO:0032139	dinucleotide insertion or deletion binding
GO:0032405	MutLalpha complex binding
GO:0042802	identical protein binding
GO:0070182	DNA polymerase binding

Biological Process

GO:0000077	DNA damage checkpoint
GO:0000082	G1/S transition of mitotic cell cycle
GO:0000083	regulation of transcription involved in G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0000722	telomere maintenance via recombination
GO:0000723	telomere maintenance
GO:0006260	DNA replication
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006272	leading strand elongation
GO:0006275	regulation of DNA replication
GO:0006281	DNA repair
GO:0006283	transcription-coupled nucleotide-excision repair
GO:0006284	base-excision repair
GO:0006289	nucleotide-excision repair
GO:0006297	nucleotide-excision repair, DNA gap filling
GO:0006298	mismatch repair
GO:0007507	heart development
GO:0008283	cell proliferation
GO:0019985	translesion synthesis
GO:0030855	epithelial cell differentiation
GO:0032077	positive regulation of deoxyribonuclease activity
GO:0032201	telomere maintenance via semi-conservative replication
GO:0033993	response to lipid
GO:0046686	response to cadmium ion
GO:0048015	phosphatidylinositol-mediated signaling

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005663	DNA replication factor C complex
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0030896	checkpoint clamp complex
GO:0043596	nuclear replication fork
GO:0043626	PCNA complex
GO:0070062	extracellular vesicular exosome
GO:0070557	PCNA-p21 complex