InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ARAP3

Summary

InnateDB Gene

IDBG-50822.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ARAP3

Gene Name

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000120318

Encoded Proteins

IDBP-50824

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

IDBP-474527

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

IDBP-476582

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

IDBP-473765

ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a phosphoinositide binding protein containing ARF-GAP, RHO-GAP, RAS-associating, and pleckstrin homology domains. The ARF-GAP and RHO-GAP domains cooperate in mediating rearrangements in the cell cytoskeleton and cell shape. It is a specific PtdIns(3,4,5)P3/PtdIns(3,4)P2-stimulated Arf6-GAP protein. An alternatively spliced transcript has been found for this gene, but its biological validity has not been determined. [provided by RefSeq, Sep 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:141653401-141682221

Strand

Reverse strand

Band

q31.3

Transcripts

ENST00000239440	ENSP00000239440
ENST00000508305	ENSP00000421826
ENST00000512390
ENST00000513878	ENSP00000421468
ENST00000504448	ENSP00000421148
ENST00000524066

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005100	Rho GTPase activator activity
GO:0005515	protein binding
GO:0005547	phosphatidylinositol-3,4,5-trisphosphate binding
GO:0008060	ARF GTPase activator activity
GO:0008270	zinc ion binding
GO:0043325	phosphatidylinositol-3,4-bisphosphate binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0008360	regulation of cell shape
GO:0016192	vesicle-mediated transport
GO:0030336	negative regulation of cell migration
GO:0032312	regulation of ARF GTPase activity
GO:0032321	positive regulation of Rho GTPase activity
GO:0035021	negative regulation of Rac protein signal transduction
GO:0035024	negative regulation of Rho protein signal transduction
GO:0043547	positive regulation of GTPase activity
GO:0051056	regulation of small GTPase mediated signal transduction

Cellular Component

GO:0001726	ruffle
GO:0005622	intracellular
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005856	cytoskeleton
GO:0005886	plasma membrane
GO:0030027	lamellipodium

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000024451

View Gene Order

ENSBTAG00000015938

Not yet available

Pathways

NETPATH

REACTOME

REACT_11051

Rho GTPase cycle pathway

REACT_11044

Signaling by Rho GTPases pathway

REACT_111102

Signal Transduction pathway

KEGG

hsa04144

Endocytosis pathway

INOH

PID NCI

pi3kcipathway

Class I PI3K signaling events

rhoa_reg_pathway

Regulation of RhoA activity

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.726187

RefSeq

NM_022481 XM_005268499 XM_005268500 XM_006714793

HUGO

OMIM

CCDS

CCDS4266

HPRD

09441

IMGT

EMBL

GenPept

RNA Seq Atlas