Homo sapiens Gene: PTPRN2 | |||||||||||||||||||
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Summary | |||||||||||||||||||
InnateDB Gene | IDBG-50943.6 | ||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||
Gene Symbol | PTPRN2 | ||||||||||||||||||
Gene Name | protein tyrosine phosphatase, receptor type, N polypeptide 2 | ||||||||||||||||||
Synonyms | IA-2beta; IAR; ICAAR; PTPRP; R-PTP-N2 | ||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||
Ensembl Gene | ENSG00000155093 | ||||||||||||||||||
Encoded Proteins |
protein tyrosine phosphatase, receptor type, N polypeptide 2
protein tyrosine phosphatase, receptor type, N polypeptide 2
protein tyrosine phosphatase, receptor type, N polypeptide 2
protein tyrosine phosphatase, receptor type, N polypeptide 2
protein tyrosine phosphatase, receptor type, N polypeptide 2
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Protein Structure | |||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||
Entrez Gene | |||||||||||||||||||
Summary |
The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single intracellular catalytic domain, and thus represents a receptor-type PTP. The catalytic domain of this PTP is most closely related to PTPRN/IA-2beta. This PTP and PTPRN are both found to be major autoantigens associated with insulin-dependent diabetes mellitus. Three alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||
Type | Protein coding | ||||||||||||||||||
Genomic Location | Chromosome 7:157539056-158587788 | ||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||
Band | q36.3 | ||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Pathways | |||||||||||||||||||
NETPATH | |||||||||||||||||||
REACTOME | |||||||||||||||||||
KEGG |
Type I diabetes mellitus pathway
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INOH | |||||||||||||||||||
PID NCI | |||||||||||||||||||
Cross-References | |||||||||||||||||||
SwissProt | |||||||||||||||||||
TrEMBL | E7EM83 Q9NSR5 | ||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||
Entrez Gene | 5799 | ||||||||||||||||||
UniGene | Hs.490789 Hs.642479 | ||||||||||||||||||
RefSeq | NM_002847 NM_130842 NM_130843 | ||||||||||||||||||
HUGO | HGNC:9677 | ||||||||||||||||||
OMIM | 601698 | ||||||||||||||||||
CCDS | CCDS5947 CCDS5948 CCDS5949 | ||||||||||||||||||
HPRD | 03413 | ||||||||||||||||||
IMGT | |||||||||||||||||||
EMBL | AC005481 AC006003 AC006372 AC011899 AC019043 AC078942 AC093662 AC093856 AC125243 AL157451 | ||||||||||||||||||
GenPept | CAB75665 | ||||||||||||||||||
RNA Seq Atlas | 5799 | ||||||||||||||||||