InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GAP43

Summary

InnateDB Gene

IDBG-50973.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GAP43

Gene Name

growth associated protein 43

Synonyms

B-50; PP46

Species

Homo sapiens

Ensembl Gene

ENSG00000172020

Encoded Proteins

IDBP-50975

growth associated protein 43

IDBP-242930

growth associated protein 43

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene has been termed a 'growth' or 'plasticity' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
The protein encoded by this gene has been termed a \'growth\' or \'plasticity\' protein because it is expressed at high levels in neuronal growth cones during development and axonal regeneration. This protein is considered a crucial component of an effective regenerative response in the nervous system. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:115623324-115721490

Strand

Forward strand

Band

q13.31

Transcripts

ENST00000305124	ENSP00000305010
ENST00000393780	ENSP00000377372

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	5 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding

Biological Process

GO:0007205	protein kinase C-activating G-protein coupled receptor signaling pathway
GO:0007399	nervous system development
GO:0007411	axon guidance
GO:0009611	response to wounding
GO:0010001	glial cell differentiation
GO:0016198	axon choice point recognition
GO:0040008	regulation of growth
GO:0042246	tissue regeneration
GO:0045165	cell fate commitment
GO:0051489	regulation of filopodium assembly

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0030054	cell junction
GO:0030424	axon
GO:0031527	filopodium membrane
GO:0032584	growth cone membrane
GO:0045202	synapse
GO:0071944	cell periphery

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000047261

View Gene Order

ENSBTAG00000006451

Not yet available

Pathways

NETPATH

NetPath_22

Leptin pathway

REACTOME

KEGG

INOH

PID NCI

ncadherinpathway

N-cadherin signaling events

Cross-References

SwissProt

P17677

TrEMBL

UniProt Splice Variant

Entrez Gene

2596

UniGene

RefSeq

NM_001130064 NM_002045

HUGO

HGNC:4140

OMIM

162060

CCDS

CCDS46890 CCDS33830

HPRD

01198

IMGT

EMBL

AC012598 AC092468 AC119795 AK289699 AK290100 AY842481 BC007936 M25667 S66533 S66534 S66541

GenPept

AAA52516 AAB28649 AAH07936 AAV88094 BAF82388 BAF82789

RNA Seq Atlas

2596