Version 5.4
Homo sapiens Gene: SCGB1A1
Summary
InnateDB Gene IDBG-50981.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCGB1A1
Gene Name secretoglobin, family 1A, member 1 (uteroglobin)
Synonyms CC10; CC16; CCPBP; CCSP; UGB; UP-1; UP1
Species Homo sapiens
Ensembl Gene ENSG00000149021
Encoded Proteins
IDBP-50983
secretoglobin, family 1A, member 1 (uteroglobin)
IDBP-592996
secretoglobin, family 1A, member 1 (uteroglobin)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the secretoglobin family of small secreted proteins. The encoded protein has been implicated in numerous functions including anti-inflammation, inhibition of phospholipase A2 and the sequestering of hydrophobic ligands. Defects in this gene are associated with a susceptibility to asthma. [provided by RefSeq, May 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62405103-62423195
Strand Forward strand
Band q12.3
Transcripts
ENST00000278282 ENSP00000278282
ENST00000534397 ENSP00000432866
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0005515 protein binding
GO:0019834 phospholipase A2 inhibitor activity
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0007565 female pregnancy
GO:0007566 embryo implantation
GO:0009410 response to xenobiotic stimulus
GO:0010033 response to organic substance
GO:0010193 response to ozone
GO:0032496 response to lipopolysaccharide
GO:0032689 negative regulation of interferon-gamma production
GO:0032696 negative regulation of interleukin-13 production
GO:0032713 negative regulation of interleukin-4 production
GO:0032714 negative regulation of interleukin-5 production
GO:0034021 response to silicon dioxide
GO:0034097 response to cytokine
GO:0042130 negative regulation of T cell proliferation
GO:0042493 response to drug
GO:0043086 negative regulation of catalytic activity
GO:0043488 regulation of mRNA stability
GO:0050727 regulation of inflammatory response
GO:0051384 response to glucocorticoid
GO:0071774 response to fibroblast growth factor
Cellular Component
GO:0005615 extracellular space
GO:0005622 intracellular
GO:0005635 nuclear envelope
GO:0005737 cytoplasm
GO:0005783 endoplasmic reticulum
GO:0005791 rough endoplasmic reticulum
GO:0030141 secretory granule
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt P11684
TrEMBL E9PN95
UniProt Splice Variant
Entrez Gene 7356
UniGene
RefSeq NM_003357
HUGO HGNC:12523
OMIM 192020
CCDS CCDS8020
HPRD
IMGT
EMBL AK312165 AP003064 BC004481 CH471076 CR541780 U01101 U01102 X13197 X59875
GenPept AAA18297 AAA81885 AAH04481 BAG35099 CAA31584 CAA42532 CAG46579 EAW74018
RNA Seq Atlas 7356

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca