Version 5.4
Homo sapiens Gene: BTG1
Summary
InnateDB Gene IDBG-51010.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BTG1
Gene Name B-cell translocation gene 1, anti-proliferative
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000133639
Encoded Proteins
IDBP-51012
B-cell translocation gene 1, anti-proliferative
IDBP-598433
B-cell translocation gene 1, anti-proliferative
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of an anti-proliferative gene family that regulates cell growth and differentiation. Expression of this gene is highest in the G0/G1 phases of the cell cycle and downregulated when cells progressed through G1. The encoded protein interacts with several nuclear receptors, and functions as a coactivator of cell differentiation. This locus has been shown to be involved in a t(8;12)(q24;q22) chromosomal translocation in a case of B-cell chronic lymphocytic leukemia. [provided by RefSeq, Oct 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:92140278-92145897
Strand Reverse strand
Band q21.33
Transcripts
ENST00000256015 ENSP00000256015
ENST00000552315 ENSP00000447551
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 34 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 34 [view]
Protein-Protein 32 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003712 transcription cofactor activity
GO:0005515 protein binding
GO:0019899 enzyme binding
GO:0019900 kinase binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006479 protein methylation
GO:0006979 response to oxidative stress
GO:0007283 spermatogenesis
GO:0008285 negative regulation of cell proliferation
GO:0016477 cell migration
GO:0030308 negative regulation of cell growth
GO:0043434 response to peptide hormone
GO:0045603 positive regulation of endothelial cell differentiation
GO:0045663 positive regulation of myoblast differentiation
GO:0045766 positive regulation of angiogenesis
GO:2000271 positive regulation of fibroblast apoptotic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036478
View Gene Order
ENSBTAG00000020330
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt P62324
TrEMBL F8W0U7 Q6IBC8
UniProt Splice Variant
Entrez Gene 694
UniGene Hs.255935 Hs.710041
RefSeq NM_001731
HUGO HGNC:1130
OMIM 109580
CCDS CCDS9043
HPRD
IMGT
EMBL AC025164 AK313309 AY850133 BC016759 BC064953 BT019839 BT019840 BT019841 CH471054 CR456876 CR541782 S38424 S38425 X61123
GenPept AAA08538 AAH16759 AAH64953 AAV38642 AAV38643 AAV38644 AAV97814 BAG36114 CAA43435 CAG33157 CAG46581 EAW97467
RNA Seq Atlas 694

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca