Version 5.4
Homo sapiens Gene: FOXA1
Summary
InnateDB Gene IDBG-5104.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FOXA1
Gene Name forkhead box A1
Synonyms HNF3A; TCF3A
Species Homo sapiens
Ensembl Gene ENSG00000129514
Encoded Proteins
IDBP-5106
forkhead box A1
IDBP-594650
forkhead box A1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the forkhead class of DNA-binding proteins. These hepatocyte nuclear factors are transcriptional activators for liver-specific transcripts such as albumin and transthyretin, and they also interact with chromatin. Similar family members in mice have roles in the regulation of metabolism and in the differentiation of the pancreas and liver. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 14:37589984-37596059
Strand Reverse strand
Band q21.1
Transcripts
ENST00000250448 ENSP00000250448
ENST00000545425
ENST00000553751 ENSP00000451704
ENST00000554607
ENST00000557418
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 23 interaction(s) predicted by orthology.
Experimentally validated
Total 23 [view]
Protein-Protein 11 [view]
Protein-DNA 12 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 23 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0006338 chromatin remodeling
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0010468 regulation of gene expression
GO:0010719 negative regulation of epithelial to mesenchymal transition
GO:0021904 dorsal/ventral neural tube patterning
GO:0030324 lung development
GO:0032355 response to estradiol
GO:0033148 positive regulation of intracellular estrogen receptor signaling pathway
GO:0035239 tube morphogenesis
GO:0042445 hormone metabolic process
GO:0042593 glucose homeostasis
GO:0045087 innate immune response
GO:0045666 positive regulation of neuron differentiation
GO:0045880 positive regulation of smoothened signaling pathway
GO:0045931 positive regulation of mitotic cell cycle
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048665 neuron fate specification
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051726 regulation of cell cycle
GO:0060441 epithelial tube branching involved in lung morphogenesis
GO:0060487 lung epithelial cell differentiation
GO:0060528 secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0060738 epithelial-mesenchymal signaling involved in prostate gland development
GO:0060740 prostate gland epithelium morphogenesis
GO:0060741 prostate gland stromal morphogenesis
GO:0060743 epithelial cell maturation involved in prostate gland development
GO:0061448 connective tissue development
GO:2000049 positive regulation of cell-cell adhesion mediated by cadherin
Cellular Component
GO:0005634 nucleus
GO:0005902 microvillus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035451
View Gene Order
ENSBTAG00000013888
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
hnf3bpathway
FOXA2 and FOXA3 transcription factor networks
p53downstreampathway
Direct p53 effectors
hnf3pathway
FOXA transcription factor networks
hnf3apathway
FOXA1 transcription factor network
Cross-References
SwissProt P55317
TrEMBL G3V4B9
UniProt Splice Variant
Entrez Gene 3169
UniGene Hs.163484
RefSeq NM_004496
HUGO HGNC:5021
OMIM 602294
CCDS CCDS9665
HPRD
IMGT
EMBL AF176111 AF176112 AF303742 AF303743 AK313785 AK316360 AL121790 BC033890 CH471078 U39840
GenPept AAB06493 AAD51979 AAG40847 AAH33890 BAG36523 BAH14731 EAW65844
RNA Seq Atlas 3169

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca