Version 5.4
Homo sapiens Gene: ARHGEF7
Summary
InnateDB Gene IDBG-51160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF7
Gene Name Rho guanine nucleotide exchange factor (GEF) 7
Synonyms BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB
Species Homo sapiens
Ensembl Gene ENSG00000102606
Encoded Proteins
IDBP-51162
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51164
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51166
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51170
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51172
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51174
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-373763
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-373790
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-373791
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-476833
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-474440
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-475499
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-477912
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-482903
Rho guanine nucleotide exchange factor (GEF) 7
IDBP-599244
Rho guanine nucleotide exchange factor (GEF) 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:111114559-111305737
Strand Forward strand
Band q34
Transcripts
ENST00000375741 ENSP00000364893
ENST00000317133 ENSP00000325994
ENST00000375739 ENSP00000364891
ENST00000375736 ENSP00000364888
ENST00000218789 ENSP00000218789
ENST00000375723 ENSP00000364875
ENST00000449979 ENSP00000406732
ENST00000426073 ENSP00000397068
ENST00000426768 ENSP00000389890
ENST00000483540
ENST00000491775 ENSP00000418043
ENST00000469877 ENSP00000418235
ENST00000466143 ENSP00000418067
ENST00000467053 ENSP00000420592
ENST00000483189
ENST00000478679 ENSP00000417596
ENST00000491688
ENST00000544132 ENSP00000445384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 62 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0030032 lamellipodium assembly
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031511
View Gene Order
ENSBTAG00000020726
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
REACT_13638
NRAGE signals death through JNK pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_18407
G alpha (12/13) signalling events pathway
REACT_11051
Rho GTPase cycle pathway
REACT_111045
Developmental Biology pathway
REACT_11061
Signalling by NGF pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_11044
Signaling by Rho GTPases pathway
REACT_14797
Signaling by GPCR pathway
REACT_18266
Axon guidance pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_228226
Ephrin signaling pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_228170
EPH-Ephrin signaling pathway
REACT_116125
Disease pathway
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
rac1_reg_pathway
Regulation of RAC1 activity
aurora_a_pathway
Aurora A signaling
erbb1_internalization_pathway
Internalization of ErbB1
fak_pathway
Signaling events mediated by focal adhesion kinase
ilk_pathway
Integrin-linked kinase signaling
cdc42_pathway
CDC42 signaling events
cdc42_reg_pathway
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735 XM_005254086 XM_005254087 XM_005254090 XM_005254091 XM_005254095
HUGO
OMIM
CCDS CCDS32009 CCDS45068 CCDS45069 CCDS9521
HPRD 05688
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca