Homo sapiens Gene: ARHGEF7
Summary
InnateDB Gene IDBG-51160.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARHGEF7
Gene Name Rho guanine nucleotide exchange factor (GEF) 7
Synonyms BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB;
Species Homo sapiens
Ensembl Gene ENSG00000102606
Encoded Proteins
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:111114559-111305737
Strand Forward strand
Band q34
Transcripts
ENST00000375741 ENSP00000364893
ENST00000317133 ENSP00000325994
ENST00000375739 ENSP00000364891
ENST00000375736 ENSP00000364888
ENST00000218789 ENSP00000218789
ENST00000375723 ENSP00000364875
ENST00000449979 ENSP00000406732
ENST00000426073 ENSP00000397068
ENST00000426768 ENSP00000389890
ENST00000483540
ENST00000491775 ENSP00000418043
ENST00000469877 ENSP00000418235
ENST00000466143 ENSP00000418067
ENST00000467053 ENSP00000420592
ENST00000483189
ENST00000478679 ENSP00000417596
ENST00000491688
ENST00000544132 ENSP00000445384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 65 [view]
Protein-Protein 62 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
Biological Process
GO:0002244 hematopoietic progenitor cell differentiation
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0030032 lamellipodium assembly
GO:0032321 positive regulation of Rho GTPase activity
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0001726 ruffle
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
G alpha (12/13) signalling events pathway
Developmental Biology pathway
Signalling by NGF pathway
Signaling by EGFR in Cancer pathway
Signaling by Rho GTPases pathway
Signaling by EGFR pathway
Signaling by GPCR pathway
Axon guidance pathway
p75 NTR receptor-mediated signalling pathway
Signal Transduction pathway
GPCR downstream signaling pathway
NRAGE signals death through JNK pathway
Ephrin signaling pathway
Rho GTPase cycle pathway
Cell death signalling via NRAGE, NRIF and NADE pathway
EGFR downregulation pathway
EPH-Ephrin signaling pathway
Disease pathway
KEGG
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Regulation of RAC1 activity
Aurora A signaling
Internalization of ErbB1
Signaling events mediated by focal adhesion kinase
Integrin-linked kinase signaling
CDC42 signaling events
Regulation of CDC42 activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735 XM_005254086 XM_005254087 XM_005254090 XM_005254091 XM_005254095
HUGO
OMIM
CCDS CCDS32009 CCDS45068 CCDS45069 CCDS9521
HPRD 05688
IMGT
EMBL
GenPept
RNA Seq Atlas