Homo sapiens Gene: ARHGEF7
Summary
InnateDB Gene IDBG-51160.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol ARHGEF7
Gene Name Rho guanine nucleotide exchange factor (GEF) 7
Synonyms BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB;
Species Homo sapiens
Ensembl Gene ENSG00000102606
Encoded Proteins
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Rho guanine nucleotide exchange factor (GEF) 7
Protein Structure
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:111766906-111958084
Strand Forward strand
Band q34
Transcripts
ENST00000375741 ENSP00000364893
ENST00000317133 ENSP00000325994
ENST00000375739 ENSP00000364891
ENST00000375737 ENSP00000364889
ENST00000375736 ENSP00000364888
ENST00000218789 ENSP00000218789
ENST00000375723 ENSP00000364875
ENST00000370623 ENSP00000359657
ENST00000449979 ENSP00000406732
ENST00000426073 ENSP00000397068
ENST00000426768 ENSP00000389890
ENST00000483540
ENST00000491775 ENSP00000418043
ENST00000469877 ENSP00000418235
ENST00000466143 ENSP00000418067
ENST00000478983
ENST00000467053 ENSP00000420592
ENST00000483189
ENST00000478679 ENSP00000417596
ENST00000491688
ENST00000544132 ENSP00000445384
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 57 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 57 [view]
Protein-Protein 57 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0019901 protein kinase binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0030032 lamellipodium assembly
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048011 nerve growth factor receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Not yet available
Non-SSD Ortholog
Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
EGFR1 pathway
TCR pathway
REACTOME
NRAGE signals death through JNK pathway
EGFR downregulation pathway
G alpha (12/13) signalling events pathway
Rho GTPase cycle pathway
KEGG
Regulation of actin cytoskeleton pathway
INOH
PID BIOCARTA
Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
Signaling events mediated by focal adhesion kinase
Integrin-linked kinase signaling
CDC42 signaling events
Regulation of CDC42 activity
Regulation of RAC1 activity
Aurora A signaling
Internalization of ErbB1
Cross-References
SwissProt Q14155
TrEMBL B1ALK5 B1ALK7 B1ANY6 B7Z6D9 B7Z6G2 C9JAD7 C9JDI6 E7ENL8 E7EU80 E7EUY6 E9PDQ5 Q5ZEZ2 Q5ZEZ3
UniProt Splice Variant
Entrez Gene 8874
UniGene
RefSeq NM_001113511 NM_001113512 NM_001113513 NM_003899 NM_145735
HUGO 15607
OMIM 605477
CCDS CCDS32009 CCDS45068 CCDS45069 CCDS9521
HPRD 05688
IMGT
EMBL AB075521 AB177849 AJ844629 AJ844631 AK300157 AK300272 AL139086 AL353704 AL390754 AL834228 BC033905 BC050521 BC060776 CH471085 D63476
GenPept AAH33905 AAH50521 AAH60776 BAA09763 BAD66827 BAE45764 BAH13225 BAH13248 CAD38906 CAH59748 CAH59949 CAI12460 CAI12461 CAI12462 CAI12463 CAI14670 CAI14671 CAI14672 CAM13628 CAM20788 EAX09143
ImmGen ARHGEF7 (murine)
RNA Seq Atlas 8874