Homo sapiens Gene: ARHGEF7

Summary
InnateDB Gene IDBG-51160.5
Last Modified 2012-02-14   [Report errors or provide feedback]
Gene Symbol ARHGEF7
Gene Name Rho guanine nucleotide exchange factor (GEF) 7
Synonyms BETA-PIX; COOL-1; COOL1; Nbla10314; P50; P50BP; P85; P85COOL1; P85SPR; PAK3; PIXB
Species Homo sapiens
Ensembl Gene ENSG00000102606
Encoded Proteins
IDBP-51162 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51164 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51166 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51168 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51170 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51172 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-51174 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-87670 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-373763 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-373790 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-373791 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-476833 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-474440 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-475499 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-477912 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-482903 Rho guanine nucleotide exchange factor (GEF) 7
IDBP-599244 Rho guanine nucleotide exchange factor (GEF) 7
Entrez Gene
Summary Rho GTPases play a fundamental role in numerous cellular processes triggered by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It forms a complex with the small GTP binding protein Rac1 and recruits Rac1 to membrane ruffles and to focal adhesions. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 13: 111766906-111958084
Strand Forward strand
Band q34
Transcripts
ENST00000375741  ENSP00000364893
ENST00000317133  ENSP00000325994
ENST00000375739  ENSP00000364891
ENST00000375737  ENSP00000364889
ENST00000375736  ENSP00000364888
ENST00000218789  ENSP00000218789
ENST00000375723  ENSP00000364875
ENST00000370623  ENSP00000359657
ENST00000449979  ENSP00000406732
ENST00000426073  ENSP00000397068
ENST00000426768  ENSP00000389890
ENST00000483540 
ENST00000491775  ENSP00000418043
ENST00000469877  ENSP00000418235
ENST00000466143  ENSP00000418067
ENST00000478983 
ENST00000467053  ENSP00000420592
ENST00000483189 
ENST00000478679  ENSP00000417596
ENST00000491688 
ENST00000544132  ENSP00000445384
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 37 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 37 [view]
Protein‑Protein  37
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Predicted by orthology
Total 6 [view]
Gene Ontology
Accession GO Term
Molecular Function
GO:0005085 guanyl-nucleotide exchange factor activity
GO:0005089 Rho guanyl-nucleotide exchange factor activity
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0019901 protein kinase binding
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007264 small GTPase mediated signal transduction
GO:0007399 nervous system development
GO:0030032 lamellipodium assembly
GO:0035023 regulation of Rho protein signal transduction
GO:0035556 intracellular signal transduction
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0043065 positive regulation of apoptotic process
GO:0043547 positive regulation of GTPase activity
GO:0048011 nerve growth factor receptor signaling pathway
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0001726 ruffle
GO:0005622 intracellular
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0043005 neuron projection
GO:0043025 neuronal cell body
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000031511 Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
ENSBTAG00000020726 Not yet available Ortholuge Non-SSD Ortholog Possible paralog/unusual divergence/ gene prediction error
Pathways
NETPATH
NetPath_4 EGFR1 pathway
NetPath_11 TCR pathway
REACTOME
REACT_12484 EGFR downregulation
REACT_18407 G alpha (12/13) signalling events
REACT_13638 NRAGE signals death through JNK
REACT_11051 Rho GTPase cycle
KEGG
hsa04810  Regulation of actin cytoskeleton
INOH
PID BIOCARTA
100252 Agrin in postsynaptic differentiation [Biocarta view]
PID NCI
aurora_a_pathway Aurora A signaling
cdc42_pathway CDC42 signaling events
ilk_pathway Integrin-linked kinase signaling
erbb1_internalization_pathway Internalization of ErbB1
cdc42_reg_pathway Regulation of CDC42 activity
rac1_reg_pathway Regulation of RAC1 activity
fak_pathway Signaling events mediated by focal adhesion kinase
Cross-References
SwissProt Q14155 
TrEMBL B1ALK5 B1ALK7 B1ANY6 B7Z6D9 B7Z6G2 C9JAD7 C9JDI6 E7ENL8 E7EU80 E7EUY6 E9PDQ5 Q5ZEZ2 Q5ZEZ3
UniProt Splice Variant
Entrez Gene 8874 
UniGene
RefSeq NM_001113511  NM_001113512  NM_001113513  NM_003899  NM_145735 
HUGO 15607 
OMIM 605477
CCDS CCDS32009  CCDS45068  CCDS45069  CCDS9521 
HPRD 05688
IMGT
EMBL AB075521 AB177849 AJ844629 AJ844631 AK300157 AK300272 AL139086 AL353704 AL390754 AL834228 BC033905 BC050521 BC060776 CH471085 D63476
GenPept AAH33905  AAH50521  AAH60776  BAA09763  BAD66827  BAE45764  BAH13225  BAH13248  CAD38906  CAH59748  CAH59949  CAI12460  CAI12461  CAI12462  CAI12463  CAI14670  CAI14671  CAI14672  CAM13628  CAM20788  EAX09143 
ImmGen ARHGEF7 (murine) 
RNA Seq Atlas 8874