InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: UBE2N

Summary

InnateDB Gene

IDBG-51220.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

UBE2N

Gene Name

ubiquitin-conjugating enzyme E2N

Synonyms

HEL-S-71; UBC13; UbcH-ben; UbcH13; UBCHBEN; UBC13

Species

Homo sapiens

Ensembl Gene

ENSG00000177889

Encoded Proteins

IDBP-51222

ubiquitin-conjugating enzyme E2N

IDBP-595113

ubiquitin-conjugating enzyme E2N

IDBP-595954

ubiquitin-conjugating enzyme E2N

IDBP-599735

ubiquitin-conjugating enzyme E2N

IDBP-598972

ubiquitin-conjugating enzyme E2N

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 16862162

UBE2N abalation resulted in defective B cell development and in impaired B cell and macrophage activation.

PMID 26101372

TRIM5 requires UBE2W, UBE2N and UBE2V2 enzymatic activities to inhibit retroviral DNA synthesis

Entrez Gene

Summary

The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. Studies in mouse suggest that this protein plays a role in DNA postreplication repair. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:93405673-93442262

Strand

Reverse strand

Band

q22

Transcripts

ENST00000318066	ENSP00000316176
ENST00000548946
ENST00000550657	ENSP00000449352
ENST00000549833	ENSP00000450260
ENST00000549490	ENSP00000447009
ENST00000552442	ENSP00000448352

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 231 experimentally validated interaction(s) in this database.
They are also associated with 17 interaction(s) predicted by orthology.

Experimentally validated
Total	231 [view]
Protein-Protein	224 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	4 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	17 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016881	acid-amino acid ligase activity
GO:0043130	ubiquitin binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000724	double-strand break repair via homologous recombination
GO:0000729	DNA double-strand break processing
GO:0002224	toll-like receptor signaling pathway
GO:0002755	MyD88-dependent toll-like receptor signaling pathway
GO:0006282	regulation of DNA repair
GO:0006301	postreplication repair
GO:0006464	cellular protein modification process
GO:0006508	proteolysis
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0008152	metabolic process
GO:0016567	protein ubiquitination
GO:0016574	histone ubiquitination
GO:0019221	cytokine-mediated signaling pathway
GO:0031058	positive regulation of histone modification
GO:0033182	regulation of histone ubiquitination
GO:0034134	toll-like receptor 2 signaling pathway
GO:0034142	toll-like receptor 4 signaling pathway
GO:0034146	toll-like receptor 5 signaling pathway
GO:0034162	toll-like receptor 9 signaling pathway
GO:0034166	toll-like receptor 10 signaling pathway
GO:0035872	nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0038123	toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124	toll-like receptor TLR6:TLR2 signaling pathway
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0045087	innate immune response (InnateDB)
GO:0045739	positive regulation of DNA repair
GO:0050852	T cell receptor signaling pathway
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051443	positive regulation of ubiquitin-protein transferase activity
GO:0070423	nucleotide-binding oligomerization domain containing signaling pathway
GO:0070534	protein K63-linked ubiquitination

Cellular Component

GO:0000151	ubiquitin ligase complex
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0031372	UBC13-MMS2 complex
GO:0035370	UBC13-UEV1A complex
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000074781

View Gene Order

ENSBTAG00000021767

Not yet available

Pathways

NETPATH

NetPath_13

IL1 pathway

REACTOME

REACT_75842

Antigen processing: Ubiquitination & Proteasome degradation pathway

REACT_25374

IKK complex recruitment mediated by RIP1 pathway

REACT_6809

MyD88-independent cascade pathway

REACT_6783

Toll Like Receptor 3 (TLR3) Cascade pathway

REACT_24918

IRAK1 recruits IKK complex pathway

REACT_6788

MyD88:Mal cascade initiated on plasma membrane pathway

REACT_8005

Toll Like Receptor TLR1:TLR2 Cascade pathway

REACT_8006

Toll Like Receptor TLR6:TLR2 Cascade pathway

REACT_25120

TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway

REACT_25354

IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway

REACT_25024

TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway

REACT_25222

MyD88 dependent cascade initiated on endosome pathway

REACT_9047

Toll Like Receptor 9 (TLR9) Cascade pathway

REACT_27215

MyD88 cascade initiated on plasma membrane pathway

REACT_9027

Toll Like Receptor 10 (TLR10) Cascade pathway

REACT_6894

Toll Like Receptor 4 (TLR4) Cascade pathway

REACT_9061

Toll Like Receptor 5 (TLR5) Cascade pathway

REACT_75776

NOD1/2 Signaling Pathway pathway

REACT_12555

Downstream TCR signaling pathway

REACT_115831

ISG15 antiviral mechanism pathway

REACT_22442

Interleukin-1 signaling pathway

REACT_163994

FCERI mediated NF-kB activation pathway

REACT_9020

Toll Like Receptor 7/8 (TLR7/8) Cascade pathway

REACT_12526

TCR signaling pathway

REACT_115676

Antiviral mechanism by IFN-stimulated genes pathway

REACT_75790

Cytokine Signaling in Immune system pathway

REACT_6802

Innate Immune System pathway

REACT_7980

Toll Like Receptor 2 (TLR2) Cascade pathway

REACT_6966

Toll-Like Receptors Cascades pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_25229

Interferon Signaling pathway

REACT_75913

Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway

REACT_75774

Adaptive Immune System pathway

REACT_6900

Immune System pathway

REACT_22232

Signaling by Interleukins pathway

REACT_6890

Activated TLR4 signalling pathway

REACT_75820

Class I MHC mediated antigen processing & presentation pathway

REACT_25281

TRIF-mediated TLR3/TLR4 signaling pathway

KEGG

hsa04120

Ubiquitin mediated proteolysis pathway

INOH

INOH website

CD4 T cell receptor signaling pathway

INOH website

IL-1 signaling pathway pathway

INOH website

Toll-like receptor signaling pathway pathway

INOH website

B cell receptor signaling pathway

PID NCI

il1pathway

IL1-mediated signaling events

atm_pathway

ATM pathway

Cross-References

SwissProt

TrEMBL

F8VV71

UniProt Splice Variant

Entrez Gene

7334

UniGene

Hs.524630 Hs.610461 Hs.619366

RefSeq

NM_001012989 NM_003348

HUGO

HGNC:12492

OMIM

603679

CCDS

CCDS31875

HPRD

04725

IMGT

EMBL

AC025260

GenPept

RNA Seq Atlas

389898 7334