Version 5.4
Homo sapiens Gene: SOCS2
Summary
InnateDB Gene IDBG-51299.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SOCS2
Gene Name suppressor of cytokine signaling 2
Synonyms CIS2; Cish2; SOCS-2; SSI-2; SSI2; STATI2
Species Homo sapiens
Ensembl Gene ENSG00000120833
Encoded Proteins
IDBP-51301
suppressor of cytokine signaling 2
IDBP-599599
suppressor of cytokine signaling 2
IDBP-591670
suppressor of cytokine signaling 2
IDBP-587981
suppressor of cytokine signaling 2
IDBP-598967
suppressor of cytokine signaling 2
IDBP-592894
suppressor of cytokine signaling 2
IDBP-603645
suppressor of cytokine signaling 2
IDBP-587903
suppressor of cytokine signaling 2
IDBP-808149
suppressor of cytokine signaling 2
IDBP-808150
suppressor of cytokine signaling 2
IDBP-808152
suppressor of cytokine signaling 2
IDBP-808153
suppressor of cytokine signaling 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 14645718
SOCS2 can enhance IL-2 and IL-3 signalling by accelerating SOCS3 degradation.
Entrez Gene
Summary This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:93569814-93583487
Strand Forward strand
Band q22
Transcripts
ENST00000340600 ENSP00000339428
ENST00000549206 ENSP00000448815
ENST00000536696 ENSP00000442898
ENST00000548091 ENSP00000447902
ENST00000549122 ENSP00000447161
ENST00000548537 ENSP00000448709
ENST00000549887 ENSP00000448611
ENST00000551556 ENSP00000449227
ENST00000547229 ENSP00000473902
ENST00000551883 ENSP00000474805
ENST00000549510 ENSP00000474888
ENST00000622746 ENSP00000481249
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 36 experimentally validated interaction(s) in this database.
Experimentally validated
Total 36 [view]
Protein-Protein 34 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005070 SH3/SH2 adaptor activity
GO:0005131 growth hormone receptor binding
GO:0005159 insulin-like growth factor receptor binding
GO:0005515 protein binding
GO:0008269 JAK pathway signal transduction adaptor activity
Biological Process
GO:0001558 regulation of cell growth
GO:0007259 JAK-STAT cascade
GO:0007568 aging
GO:0009966 regulation of signal transduction
GO:0009967 positive regulation of signal transduction
GO:0016567 protein ubiquitination
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0035556 intracellular signal transduction
GO:0043066 negative regulation of apoptotic process
GO:0043434 response to peptide hormone
GO:0045087 innate immune response (InnateDB)
GO:0046426 negative regulation of JAK-STAT cascade
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000050974
View Gene Order
ENSBTAG00000012007
Not yet available
Pathways
NETPATH
NetPath_15
IL3 pathway
NetPath_22
Leptin pathway
NetPath_56
Prolactin pathway
REACTOME
REACT_111133
Growth hormone receptor signaling pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_6900
Immune System pathway
KEGG
hsa04910
Insulin signaling pathway pathway
hsa04630
Jak-STAT signaling pathway pathway
hsa04930
Type II diabetes mellitus pathway
INOH
INOH website
JAK STAT pathway and regulation pathway
INOH website
Growth hormone signaling pathway
PID NCI
il2_1pathway
IL2-mediated signaling events
Cross-References
SwissProt
TrEMBL F8VU91
UniProt Splice Variant
Entrez Gene 8835
UniGene Hs.594327 Hs.609535 Hs.612640 Hs.738912
RefSeq NM_001270467 NM_001270468 NM_001270469 NM_001270470 NM_001270471 NM_003877 XM_006719673
HUGO HGNC:19382
OMIM 605117
CCDS CCDS9047
HPRD 05490
IMGT
EMBL AC012085
GenPept
RNA Seq Atlas 8835

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca