Version 5.4
Homo sapiens Gene: ROM1
Summary
InnateDB Gene IDBG-51305.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ROM1
Gene Name retinal outer segment membrane protein 1
Synonyms ROM; ROSP1; RP7; TSPAN23
Species Homo sapiens
Ensembl Gene ENSG00000149489
Encoded Proteins
IDBP-51307
retinal outer segment membrane protein 1
IDBP-597767
retinal outer segment membrane protein 1
IDBP-583378
retinal outer segment membrane protein 1
IDBP-598166
retinal outer segment membrane protein 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of a photoreceptor-specific gene family and encodes an integral membrane protein found in the photoreceptor disk rim of the eye. This protein can form homodimers or can heterodimerize with another photoreceptor, retinal degeneration slow (RDS). It is essential for disk morphogenesis, and may also function as an adhesion molecule involved in the stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. Certain defects in this gene have been associated with the degenerative eye disease retinitis pigmentosa. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:62611722-62615120
Strand Forward strand
Band q12.3
Transcripts
ENST00000278833 ENSP00000278833
ENST00000525801 ENSP00000433566
ENST00000534093 ENSP00000432151
ENST00000529273
ENST00000525947 ENSP00000432983
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0007601 visual perception
GO:0010468 regulation of gene expression
GO:0060042 retina morphogenesis in camera-type eye
GO:0060219 camera-type eye photoreceptor cell differentiation
GO:0061298 retina vasculature development in camera-type eye
Cellular Component
GO:0001750 photoreceptor outer segment
GO:0005887 integral component of plasma membrane
GO:0016021 integral component of membrane
GO:0042622 photoreceptor outer segment membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071648
View Gene Order
ENSBTAG00000001188
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.281564
RefSeq NM_000327
HUGO
OMIM
CCDS CCDS8024
HPRD 01616
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca