Version 5.4
Homo sapiens Gene: ADPRH
Summary
InnateDB Gene IDBG-51326.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADPRH
Gene Name ADP-ribosylarginine hydrolase
Synonyms ARH1
Species Homo sapiens
Ensembl Gene ENSG00000144843
Encoded Proteins
IDBP-51328
ADP-ribosylarginine hydrolase
IDBP-485340
ADP-ribosylarginine hydrolase
IDBP-481378
ADP-ribosylarginine hydrolase
IDBP-477648
ADP-ribosylarginine hydrolase
IDBP-484270
ADP-ribosylarginine hydrolase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes, which require DTT for maximal activity, the human enzyme is DTT-independent. [provided by RefSeq, Jul 2008]
The enzyme encoded by this gene catalyzes removal of mono-ADP-ribose from arginine residues of proteins in the ADP-ribosylation cycle. Unlike the rat and mouse enzymes that require DTT for maximal activity, the human enzyme is DTT-independent. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, May 2014]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:119579268-119589945
Strand Forward strand
Band q13.33
Transcripts
ENST00000357003 ENSP00000349496
ENST00000478399 ENSP00000420200
ENST00000481816 ENSP00000419703
ENST00000471850
ENST00000485496
ENST00000478927 ENSP00000417528
ENST00000465513 ENSP00000417430
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0003875 ADP-ribosylarginine hydrolase activity
Biological Process
GO:0006464 cellular protein modification process
GO:0051725 protein de-ADP-ribosylation
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002844
View Gene Order
ENSBTAG00000009391
Not yet available
Cross-References
SwissProt P54922
TrEMBL C9JZW7
UniProt Splice Variant
Entrez Gene 141
UniGene Hs.99884
RefSeq NM_001125 NM_001291949
HUGO HGNC:269
OMIM 603081
CCDS CCDS2990
HPRD 04359
IMGT
EMBL AC073352 AK313369 BC063883 BC074769 CH471052 L13291
GenPept AAA35555 AAH63883 AAH74769 BAG36168 EAW79562 EAW79563
RNA Seq Atlas 141

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca