Version 5.4
Homo sapiens Gene: SMS
Summary
InnateDB Gene IDBG-51494.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SMS
Gene Name spermine synthase
Synonyms MRSR; SPMSY; SpS; SRS
Species Homo sapiens
Ensembl Gene ENSG00000102172
Encoded Proteins
IDBP-51500
spermine synthase
IDBP-294851
spermine synthase
IDBP-365311
spermine synthase
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein belonging to the spermidine/spermin synthase family. Pseudogenes of this gene are located on chromosomes 1, 5, 6 and X. Mutations in this gene are associated with X-linked Snyder-Robinson mental retardation syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome X:21940573-21994835
Strand Forward strand
Band p22.11
Transcripts
ENST00000379404 ENSP00000368714
ENST00000404933 ENSP00000385746
ENST00000457085 ENSP00000407366
ENST00000478094
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 32 experimentally validated interaction(s) in this database.
Experimentally validated
Total 32 [view]
Protein-Protein 32 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0016768 spermine synthase activity
Biological Process
GO:0006555 methionine metabolic process
GO:0006595 polyamine metabolic process
GO:0006597 spermine biosynthetic process
GO:0034641 cellular nitrogen compound metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000071708
View Gene Order
ENSBTAG00000018382
Not yet available
Pathways
NETPATH
REACTOME
REACT_14820
Metabolism of polyamines pathway
REACT_13
Metabolism of amino acids and derivatives pathway
REACT_111217
Metabolism pathway
KEGG
hsa00330
Arginine and proline metabolism pathway
hsa00480
Glutathione metabolism pathway
hsa00410
beta-Alanine metabolism pathway
hsa00270
Cysteine and methionine metabolism pathway
INOH
INOH website
Arginine Proline metabolism pathway
PID NCI
Cross-References
SwissProt P52788
TrEMBL
UniProt Splice Variant
Entrez Gene 6611
UniGene Hs.288487 Hs.634016 Hs.662446
RefSeq NM_001258423 NM_004595 XM_005274582
HUGO HGNC:11123
OMIM 300105
CCDS CCDS14203 CCDS59161
HPRD
IMGT
EMBL AD001528 AK313834 BC009898 BC085621 CH471074 U53331 U73023 Z49099
GenPept AAB61308 AAD08634 AAH09898 AAH85621 BAG36567 CAA88921 EAW98984
RNA Seq Atlas 6611

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca