Version 5.4
Homo sapiens Gene: RAMP2
Summary
InnateDB Gene IDBG-51615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAMP2
Gene Name receptor (G protein-coupled) activity modifying protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000131477
Encoded Proteins
IDBP-51617
receptor (G protein-coupled) activity modifying protein 2
IDBP-759549
IDBP-758182
IDBP-760062
IDBP-759085
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42758447-42763041
Strand Forward strand
Band q21.2
Transcripts
ENST00000253796 ENSP00000253796
ENST00000588928 ENSP00000466980
ENST00000587142 ENSP00000466455
ENST00000588576 ENSP00000465725
ENST00000591972
ENST00000589683 ENSP00000467463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008565 protein transporter activity
GO:0015026 coreceptor activity
Biological Process
GO:0001525 angiogenesis
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0002040 sprouting angiogenesis
GO:0006171 cAMP biosynthetic process
GO:0006816 calcium ion transport
GO:0006886 intracellular protein transport
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007507 heart development
GO:0007565 female pregnancy
GO:0008217 regulation of blood pressure
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0010628 positive regulation of gene expression
GO:0015031 protein transport
GO:0030819 positive regulation of cAMP biosynthetic process
GO:0031623 receptor internalization
GO:0032355 response to estradiol
GO:0032570 response to progesterone
GO:0032870 cellular response to hormone stimulus
GO:0034333 adherens junction assembly
GO:0035924 cellular response to vascular endothelial growth factor stimulus
GO:0043116 negative regulation of vascular permeability
GO:0045766 positive regulation of angiogenesis
GO:0070830 tight junction assembly
GO:0070831 basement membrane assembly
GO:0072659 protein localization to plasma membrane
GO:0097084 vascular smooth muscle cell development
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2001214 positive regulation of vasculogenesis
Cellular Component
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005905 coated pit
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0043235 receptor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000001240
View Gene Order
ENSBTAG00000019903
Not yet available
Pathways
NETPATH
REACTOME
REACT_19327
G alpha (s) signalling events pathway
REACT_18290
Calcitonin-like ligand receptors pathway
REACT_18372
Class B/2 (Secretin family receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
hsa04270
Vascular smooth muscle contraction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.514193
RefSeq NM_005854
HUGO
OMIM
CCDS CCDS11437
HPRD 05516
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca