Homo sapiens Gene: NR3C1 | |||||||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-51637.6 | ||||||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||||||
Gene Symbol | NR3C1 | ||||||||||||||||||||||||||||||||||||||
Gene Name | nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor) | ||||||||||||||||||||||||||||||||||||||
Synonyms | GCCR; GCR; GCRST; GR; GRL | ||||||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000113580 | ||||||||||||||||||||||||||||||||||||||
Encoded Proteins |
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
nuclear receptor subfamily 3, group C, member 1 (glucocorticoid receptor)
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Protein Structure | |||||||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||||||||||||||||||
Summary |
The Glucocorticoid receptor, NR3C1, exerts anti-inflammatory action in part by antagonizing pro-inflammatory transcription factors such as RELA of the NFkB complex.
NR3C1, the glucocorticoid receptor, is necessary for glucocorticoid-mediated induction of NLRP3 and the subsequent formation of inflammasomes, demonstrating a novel role for glucocorticoids in sensitizing the initial inflammatory response by the innate immune system. (Demonstrated in mice)
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||||||||||||||||||
Summary |
[Mus musculus] The Glucocorticoid receptor, Nr3c1 exerts anti-inflammatory action in part by antagonizing pro-inflammatory transcription factors such as Rela of the NFkB complex. (Demonstrated in human)
[Mus musculus] Nr3c1, the glucocorticoid receptor, is necessary for glucocorticoid-mediated induction of Nlrp3 and the subsequent formation of inflammasomes, demonstrating a novel role for glucocorticoids in sensitizing the initial inflammatory response by the innate immune system.
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Entrez Gene | |||||||||||||||||||||||||||||||||||||||
Summary |
This gene encodes glucocorticoid receptor, which can function both as a transcription factor that binds to glucocorticoid response elements in the promoters of glucocorticoid responsive genes to activate their transcription, and as a regulator of other transcription factors. This receptor is typically found in the cytoplasm, but upon ligand binding, is transported into the nucleus. It is involved in inflammatory responses, cellular proliferation, and differentiation in target tissues. Mutations in this gene are associated with generalized glucocorticoid resistance. Alternative splicing of this gene results in transcript variants encoding either the same or different isoforms. Additional isoforms resulting from the use of alternate in-frame translation initiation sites have also been described, and shown to be functional, displaying diverse cytoplasm-to-nucleus trafficking patterns and distinct transcriptional activities (PMID:15866175). [provided by RefSeq, Feb 2011] |
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Gene Information | |||||||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 5:143277931-143435512 | ||||||||||||||||||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||||||||||||||||||
Band | q31.3 | ||||||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 227 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||||||
NETPATH |
AndrogenReceptor pathway
IL2 pathway
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REACTOME |
BMAL1:CLOCK,NPAS2 activates circadian gene expression pathway
Circadian Clock pathway
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KEGG |
Neuroactive ligand-receptor interaction pathway
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INOH | |||||||||||||||||||||||||||||||||||||||
PID NCI |
FOXA2 and FOXA3 transcription factor networks
AP-1 transcription factor network
Glucocorticoid receptor regulatory network
Signaling events mediated by HDAC Class II
Regulation of nuclear SMAD2/3 signaling
Regulation of Androgen receptor activity
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Cross-References | |||||||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||||||
UniGene | Hs.122926 Hs.594735 | ||||||||||||||||||||||||||||||||||||||
RefSeq | NM_000176 NM_001018074 NM_001018075 NM_001018076 NM_001018077 NM_001020825 NM_001024094 NM_001204258 NM_001204259 NM_001204260 NM_001204261 NM_001204262 NM_001204263 NM_001204264 XM_005268419 XM_005268420 XM_005268421 XM_005268422 XM_005268423 | ||||||||||||||||||||||||||||||||||||||
HUGO | |||||||||||||||||||||||||||||||||||||||
OMIM | |||||||||||||||||||||||||||||||||||||||
CCDS | CCDS34258 CCDS4278 CCDS47298 | ||||||||||||||||||||||||||||||||||||||
HPRD | 00679 | ||||||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||||||
EMBL | |||||||||||||||||||||||||||||||||||||||
GenPept | |||||||||||||||||||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||||||||||||||||||