Version 5.4
Homo sapiens Gene: FSTL1
Summary
InnateDB Gene IDBG-51777.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FSTL1
Gene Name follistatin-like 1
Synonyms FRP; FSL1; MIR198
Species Homo sapiens
Ensembl Gene ENSG00000163430
Encoded Proteins
IDBP-51779
follistatin-like 1
IDBP-382830
follistatin-like 1
IDBP-479105
follistatin-like 1
IDBP-481094
follistatin-like 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 22265692
FSTL1 acts as an endogenous TLR4 agonist and has the ability to induce IL6 and IL8 production. Similar to LPS, FSTL1 induces tolerance to subsequent LPS stimulations.
InnateDB Annotation from Orthologs
Summary
PMID 22265692
[Mus musculus] Fstl1 acts as an endogenous Tlr4 agonist. Similar to LPS, Fstl1 induces tolerance to subsequent LPS stimulations.
Entrez Gene
Summary This gene encodes a protein with similarity to follistatin, an activin-binding protein. It contains an FS module, a follistatin-like sequence containing 10 conserved cysteine residues. This gene product is thought to be an autoantigen associated with rheumatoid arthritis. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:120392293-120451253
Strand Reverse strand
Band q13.33
Transcripts
ENST00000295633 ENSP00000295633
ENST00000424703 ENSP00000394355
ENST00000480823 ENSP00000418389
ENST00000488318
ENST00000468098
ENST00000469005 ENSP00000418505
ENST00000464690
ENST00000472536
ENST00000485968
ENST00000467994
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
Experimentally validated
Total 16 [view]
Protein-Protein 16 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008201 heparin binding
Biological Process
GO:0030509 BMP signaling pathway
GO:0042594 response to starvation
GO:0045087 innate immune response (InnateDB)
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022816
View Gene Order
ENSBTAG00000022155
Not yet available
Pathways
NETPATH
REACTOME
REACT_12034
Signaling by BMP pathway
REACT_111102
Signal Transduction pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.269512 Hs.42419 Hs.617880
RefSeq NM_007085
HUGO
OMIM
CCDS CCDS2998
HPRD 16120
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca