InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: TAF6L

Summary

InnateDB Gene

IDBG-51800.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

TAF6L

Gene Name

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

Synonyms

PAF65A

Species

Homo sapiens

Ensembl Gene

ENSG00000162227

Encoded Proteins

IDBP-51802

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

IDBP-592339

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

IDBP-596172

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

IDBP-584447

TAF6-like RNA polymerase II, p300/CBP-associated factor (PCAF)-associated factor, 65kDa

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes a protein that is a component of the PCAF histone acetylase complex and structurally similar to one of the histone-like TAFs, TAF6. The PCAF histone acetylase complex, which is composed of more than 20 polypeptides some of which are TAFs, is required for myogenic transcription and differentiation. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:62771303-62787342

Strand

Forward strand

Band

q12.3

Transcripts

ENST00000294168	ENSP00000294168
ENST00000526261	ENSP00000435116
ENST00000525405	ENSP00000435443
ENST00000524976
ENST00000532915
ENST00000529509	ENSP00000434662
ENST00000531265
ENST00000533823

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	15 [view]
Protein-Protein	15 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003713	transcription coactivator activity
GO:0004402	histone acetyltransferase activity
GO:0005515	protein binding
GO:0046982	protein heterodimerization activity

Biological Process

GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006352	DNA-templated transcription, initiation
GO:0006357	regulation of transcription from RNA polymerase II promoter
GO:0043966	histone H3 acetylation
GO:0051090	regulation of sequence-specific DNA binding transcription factor activity

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0030914	STAGA complex

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000003680

View Gene Order

ENSBTAG00000009484

Not yet available

Pathways

NETPATH

REACTOME

REACT_172610

HATs acetylate histones pathway

REACT_172623

Chromatin organization pathway

REACT_172633

Chromatin modifying enzymes pathway

KEGG

hsa03022

Basal transcription factors pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

E9PK90

UniProt Splice Variant

Entrez Gene

10629

UniGene

Hs.714400

RefSeq

NM_006473

HUGO

HGNC:17305

OMIM

602946

CCDS

CCDS8035

HPRD

04253

IMGT

EMBL

AP001160

GenPept

RNA Seq Atlas

10629