Version 5.4
Homo sapiens Gene: AOC2
Summary
InnateDB Gene IDBG-51850.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AOC2
Gene Name amine oxidase, copper containing 2 (retina-specific)
Synonyms DAO2; RAO
Species Homo sapiens
Ensembl Gene ENSG00000131480
Encoded Proteins
IDBP-51852
amine oxidase, copper containing 2 (retina-specific)
IDBP-379140
amine oxidase, copper containing 2 (retina-specific)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Copper amine oxidases catalyze the oxidative conversion of amines to aldehydes and ammonia in the presence of copper and quinone cofactor. This gene shows high sequence similarity to copper amine oxidases from various species ranging from bacteria to mammals. The protein contains several conserved motifs including the active site of amine oxidases and the histidine residues that likely bind copper. It may be a critical modulator of signal transmission in retina, possibly by degrading the biogenic amines dopamine, histamine, and putrescine. This gene may be a candidate gene for hereditary ocular diseases. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:42844600-42850707
Strand Forward strand
Band q21.31
Transcripts
ENST00000253799 ENSP00000253799
ENST00000452774 ENSP00000406134
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0008131 primary amine oxidase activity
GO:0009055 electron carrier activity
GO:0048038 quinone binding
GO:0052593 tryptamine:oxygen oxidoreductase (deaminating) activity
GO:0052594 aminoacetone:oxygen oxidoreductase(deaminating) activity
GO:0052595 aliphatic-amine oxidase activity
GO:0052596 phenethylamine:oxygen oxidoreductase (deaminating) activity
Biological Process
GO:0006584 catecholamine metabolic process
GO:0007601 visual perception
GO:0009308 amine metabolic process
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000078651
View Gene Order
ENSBTAG00000030334
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa00360
Phenylalanine metabolism pathway
hsa00260
Glycine, serine and threonine metabolism pathway
hsa00350
Tyrosine metabolism pathway
hsa00410
beta-Alanine metabolism pathway
INOH
INOH website
Tryptophan degradation pathway
INOH website
Phenylalanine degradation pathway
INOH website
Arginine Proline metabolism pathway
INOH website
Tyrosine metabolism pathway
INOH website
Glycine Serine metabolism pathway
INOH website
Histidine degradation pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.143102
RefSeq NM_001158 NM_009590
HUGO
OMIM
CCDS CCDS11443 CCDS45690
HPRD 11889
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca