InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SNRPA

Summary

InnateDB Gene

IDBG-52147.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SNRPA

Gene Name

small nuclear ribonucleoprotein polypeptide A

Synonyms

Mud1; U1-A; U1A

Species

Homo sapiens

Ensembl Gene

ENSG00000077312

Encoded Proteins

IDBP-52149

small nuclear ribonucleoprotein polypeptide A

IDBP-762101

IDBP-764427

IDBP-764609

IDBP-765402

IDBP-762903

IDBP-765811

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]
The protein encoded by this gene associates with stem loop II of the U1 small nuclear ribonucleoprotein, which binds the 5\' splice site of precursor mRNAs and is required for splicing. The encoded protein autoregulates itself by polyadenylation inhibition of its own pre-mRNA via dimerization and has been implicated in the coupling of splicing and polyadenylation. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:40750637-40765389

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000243563	ENSP00000243563
ENST00000597353	ENSP00000472449
ENST00000601253	ENSP00000469224
ENST00000601393	ENSP00000472355
ENST00000598923
ENST00000596860
ENST00000599570
ENST00000599362	ENSP00000472258
ENST00000600456	ENSP00000471230
ENST00000598452
ENST00000601545	ENSP00000470534

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 95 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	95 [view]
Protein-Protein	83 [view]
Protein-DNA	10 [view]
Protein-RNA	1 [view]
DNA-DNA	0
RNA-RNA	1 [view]
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000166	nucleotide binding
GO:0003676	nucleic acid binding
GO:0003723	RNA binding
GO:0005515	protein binding
GO:0017069	snRNA binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000398	mRNA splicing, via spliceosome
GO:0008380	RNA splicing
GO:0010467	gene expression

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005681	spliceosomal complex
GO:0005685	U1 snRNP
GO:0005730	nucleolus
GO:0005737	cytoplasm

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000061479

View Gene Order

ENSBTAG00000009077

Not yet available

Pathways

NETPATH

REACTOME

REACT_467

mRNA Splicing - Major Pathway pathway

REACT_125

Processing of Capped Intron-Containing Pre-mRNA pathway

REACT_1735

mRNA Splicing pathway

REACT_71

Gene Expression pathway

KEGG

hsa03040

Spliceosome pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

M0QXK2

UniProt Splice Variant

Entrez Gene

6626

UniGene

Hs.466775

RefSeq

NM_004596

HUGO

HGNC:11151

OMIM

182285

CCDS

CCDS12565

HPRD

01658

IMGT

EMBL

AC020945

GenPept

RNA Seq Atlas

6626