Version 5.4
Homo sapiens Gene: FERMT1
Summary
InnateDB Gene IDBG-52257.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FERMT1
Gene Name fermitin family member 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000101311
Encoded Proteins
IDBP-52259
fermitin family member 1
IDBP-52263
fermitin family member 1
IDBP-589697
fermitin family member 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the fermitin family, and contains a FERM domain and a pleckstrin homology domain. The encoded protein is involved in integrin signaling and linkage of the actin cytoskeleton to the extracellular matrix. Mutations in this gene have been linked to Kindler syndrome. [provided by RefSeq, Dec 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 20:6074845-6123544
Strand Reverse strand
Band p12.3
Transcripts
ENST00000217289 ENSP00000217289
ENST00000378844 ENSP00000368121
ENST00000478194
ENST00000536936 ENSP00000441063
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007155 cell adhesion
GO:0043616 keratinocyte proliferation
GO:0051546 keratinocyte migration
GO:0090162 establishment of epithelial cell polarity
Cellular Component
GO:0005829 cytosol
GO:0005925 focal adhesion
GO:0030054 cell junction
GO:0031941 filamentous actin
GO:0032587 ruffle membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000027356
View Gene Order
ENSBTAG00000020465
Not yet available
Cross-References
SwissProt Q9BQL6
TrEMBL G3V1L6 Q5JWV4
UniProt Splice Variant
Entrez Gene 55612
UniGene Hs.472054 Hs.624409
RefSeq NM_017671
HUGO HGNC:15889
OMIM 607900
CCDS CCDS13098
HPRD
IMGT
EMBL AF443278 AK000123 AK000747 AK092195 AL118505 AY137240 BC035882 CH471133
GenPept AAH35882 AAM94174 AAN75822 BAA90957 BAA91358 BAC03826 CAC03433 EAX10392 EAX10393 EAX10395
RNA Seq Atlas 55612

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca