InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SAT1

Summary

InnateDB Gene

IDBG-52302.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SAT1

Gene Name

spermidine/spermine N1-acetyltransferase 1

Synonyms

DC21; KFSD; KFSDX; SAT; SSAT; SSAT-1

Species

Homo sapiens

Ensembl Gene

ENSG00000130066

Encoded Proteins

IDBP-52304

spermidine/spermine N1-acetyltransferase 1

IDBP-52306

spermidine/spermine N1-acetyltransferase 1

IDBP-52308

spermidine/spermine N1-acetyltransferase 1

IDBP-52310

spermidine/spermine N1-acetyltransferase 1

IDBP-811238

spermidine/spermine N1-acetyltransferase 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the acetyltransferase family, and is a rate-limiting enzyme in the catabolic pathway of polyamine metabolism. It catalyzes the acetylation of spermidine and spermine, and is involved in the regulation of the intracellular concentration of polyamines and their transport out of cells. Defects in this gene are associated with keratosis follicularis spinulosa decalvans (KFSD). Alternatively spliced transcripts have been found for this gene.[provided by RefSeq, Sep 2009]

Gene Information

Type

Protein coding

Genomic Location

Chromosome X:23783158-23786226

Strand

Forward strand

Band

p22.11

Transcripts

ENST00000379270	ENSP00000368572
ENST00000379254	ENSP00000368556
ENST00000379253	ENSP00000368555
ENST00000379251	ENSP00000368553
ENST00000489394
ENST00000463236
ENST00000487713
ENST00000474223
ENST00000462639
ENST00000612412	ENSP00000483974

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 65 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	65 [view]
Protein-Protein	65 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004145	diamine N-acetyltransferase activity
GO:0005515	protein binding
GO:0008080	N-acetyltransferase activity
GO:0019809	spermidine binding

Biological Process

GO:0001525	angiogenesis
GO:0006595	polyamine metabolic process
GO:0006596	polyamine biosynthetic process
GO:0006598	polyamine catabolic process
GO:0008152	metabolic process
GO:0009447	putrescine catabolic process
GO:0032918	spermidine acetylation
GO:0034641	cellular nitrogen compound metabolic process
GO:0042127	regulation of cell proliferation
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000025283

View Gene Order

ENSBTAG00000017363

Not yet available

Pathways

NETPATH

REACTOME

REACT_14805

Interconversion of polyamines pathway

REACT_14820

Metabolism of polyamines pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00330

Arginine and proline metabolism pathway

INOH

INOH website

Arginine Proline metabolism pathway

PID NCI

integrin_a9b1_pathway

Alpha9 beta1 integrin signaling events

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_002970

HUGO

OMIM

CCDS

CCDS14207

HPRD

02431

IMGT

EMBL

GenPept

RNA Seq Atlas