Version 5.4
Homo sapiens Gene: RPS27A
Summary
InnateDB Gene IDBG-52358.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RPS27A
Gene Name ribosomal protein S27a
Synonyms CEP80; HEL112; S27A; UBA80; UBC; UBCEP1; UBCEP80
Species Homo sapiens
Ensembl Gene ENSG00000143947
Encoded Proteins
IDBP-52360
ribosomal protein S27a
IDBP-293312
ribosomal protein S27a
IDBP-293306
ribosomal protein S27a
IDBP-376214
ribosomal protein S27a
IDBP-812989
ribosomal protein S27a
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Ubiquitin, a highly conserved protein that has a major role in targeting cellular proteins for degradation by the 26S proteosome, is synthesized as a precursor protein consisting of either polyubiquitin chains or a single ubiquitin fused to an unrelated protein. This gene encodes a fusion protein consisting of ubiquitin at the N terminus and ribosomal protein S27a at the C terminus. When expressed in yeast, the protein is post-translationally processed, generating free ubiquitin monomer and ribosomal protein S27a. Ribosomal protein S27a is a component of the 40S subunit of the ribosome and belongs to the S27AE family of ribosomal proteins. It contains C4-type zinc finger domains and is located in the cytoplasm. Pseudogenes derived from this gene are present in the genome. As with ribosomal protein S27a, ribosomal protein L40 is also synthesized as a fusion protein with ubiquitin; similarly, ribosomal protein S30 is synthesized as a fusion protein with the ubiquitin-like protein fubi. Multiple alternatively spliced transcript variants that encode the same proteins have been identified.[provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:55231903-55235853
Strand Forward strand
Band p16.1
Transcripts
ENST00000272317 ENSP00000272317
ENST00000402285 ENSP00000383981
ENST00000404735 ENSP00000385659
ENST00000449323 ENSP00000408482
ENST00000463185
ENST00000471772
ENST00000478196
ENST00000494756
ENST00000495843
ENST00000468810
ENST00000611893 ENSP00000479245
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 300 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 300 [view]
Protein-Protein 296 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003735 structural constituent of ribosome
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000086 G2/M transition of mitotic cell cycle
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000187 activation of MAPK activity
GO:0000209 protein polyubiquitination
GO:0000278 mitotic cell cycle
GO:0002224 toll-like receptor signaling pathway
GO:0002474 antigen processing and presentation of peptide antigen via MHC class I
GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent
GO:0002755 MyD88-dependent toll-like receptor signaling pathway
GO:0002756 MyD88-independent toll-like receptor signaling pathway
GO:0005975 carbohydrate metabolic process
GO:0005978 glycogen biosynthetic process
GO:0006006 glucose metabolic process
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0006915 apoptotic process
GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0007220 Notch receptor processing
GO:0007249 I-kappaB kinase/NF-kappaB signaling
GO:0007254 JNK cascade
GO:0008543 fibroblast growth factor receptor signaling pathway
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0016197 endosomal transport
GO:0019058 viral life cycle
GO:0019068 virion assembly
GO:0019082 viral protein processing
GO:0019083 viral transcription
GO:0019221 cytokine-mediated signaling pathway
GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway
GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process
GO:0032479 regulation of type I interferon production
GO:0032480 negative regulation of type I interferon production
GO:0032481 positive regulation of type I interferon production
GO:0034134 toll-like receptor 2 signaling pathway
GO:0034138 toll-like receptor 3 signaling pathway
GO:0034142 toll-like receptor 4 signaling pathway
GO:0034146 toll-like receptor 5 signaling pathway
GO:0034162 toll-like receptor 9 signaling pathway
GO:0034166 toll-like receptor 10 signaling pathway
GO:0034220 ion transmembrane transport
GO:0035666 TRIF-dependent toll-like receptor signaling pathway
GO:0035872 nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
GO:0038095 Fc-epsilon receptor signaling pathway
GO:0038123 toll-like receptor TLR1:TLR2 signaling pathway
GO:0038124 toll-like receptor TLR6:TLR2 signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I
GO:0042981 regulation of apoptotic process
GO:0043065 positive regulation of apoptotic process
GO:0043066 negative regulation of apoptotic process
GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
GO:0045087 innate immune response
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048011 neurotrophin TRK receptor signaling pathway
GO:0050852 T cell receptor signaling pathway
GO:0051092 positive regulation of NF-kappaB transcription factor activity
GO:0051403 stress-activated MAPK cascade
GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle
GO:0055085 transmembrane transport
GO:0061024 membrane organization
GO:0061418 regulation of transcription from RNA polymerase II promoter in response to hypoxia
GO:0070423 nucleotide-binding oligomerization domain containing signaling pathway
GO:0071456 cellular response to hypoxia
GO:0075733 intracellular transport of virus
GO:0097190 apoptotic signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005654 nucleoplasm
GO:0005829 cytosol
GO:0005840 ribosome
GO:0005886 plasma membrane
GO:0010008 endosome membrane
GO:0015935 small ribosomal subunit
GO:0016020 membrane
GO:0022627 cytosolic small ribosomal subunit
GO:0030666 endocytic vesicle membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020460
View Gene Order
ENSBTAG00000015473
Not yet available
Pathways
NETPATH
REACTOME
REACT_20549
Autodegradation of the E3 ubiquitin ligase COP1 pathway
REACT_309
Stabilization of p53 pathway
REACT_1625
p53-Dependent G1 DNA Damage Response pathway
REACT_1614
Ubiquitin Mediated Degradation of Phosphorylated Cdc25A pathway
REACT_2160
p53-Independent DNA Damage Response pathway
REACT_6761
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 pathway
REACT_6820
APC/C:Cdc20 mediated degradation of Cyclin B pathway
REACT_6871
APC/C:Cdc20 mediated degradation of Securin pathway
REACT_6781
APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_6785
Autodegradation of Cdh1 by Cdh1:APC/C pathway
REACT_6821
SCF-beta-TrCP mediated degradation of Emi1 pathway
REACT_6837
Regulation of APC/C activators between G1/S and early anaphase pathway
REACT_1221
CDK-mediated phosphorylation and removal of Cdc6 pathway
REACT_1156
Orc1 removal from chromatin pathway
REACT_207
Removal of licensing factors from origins pathway
REACT_1181
Association of licensing factors with the pre-replicative complex pathway
REACT_150471
Separation of Sister Chromatids pathway
REACT_4
Ubiquitin-dependent degradation of Cyclin D1 pathway
REACT_2148
Switching of origins to a post-replicative state pathway
REACT_9003
SCF(Skp2)-mediated degradation of p27/p21 pathway
REACT_9029
Cyclin A:Cdk2-associated events at S phase entry pathway
REACT_1949
CDT1 association with the CDC6:ORC:origin complex pathway
REACT_2243
Assembly of the pre-replicative complex pathway
REACT_1574
Cyclin E associated events during G1/S transition pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_160315
Regulation of PLK1 Activity at G2/M Transition pathway
REACT_75842
Antigen processing: Ubiquitination & Proteasome degradation pathway
REACT_111178
ER-Phagosome pathway pathway
REACT_25271
Negative regulators of RIG-I/MDA5 signaling pathway
REACT_25359
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
REACT_21368
JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 pathway
REACT_21399
activated TAK1 mediates p38 MAPK activation pathway
REACT_25351
TRAF6 mediated induction of TAK1 complex pathway
REACT_25374
IKK complex recruitment mediated by RIP1 pathway
REACT_21281
TAK1 activates NFkB by phosphorylation and activation of IKKs complex pathway
REACT_25148
Activation of IRF3/IRF7 mediated by TBK1/IKK epsilon pathway
REACT_6809
MyD88-independent cascade pathway
REACT_6783
Toll Like Receptor 3 (TLR3) Cascade pathway
REACT_24918
IRAK1 recruits IKK complex pathway
REACT_25380
IRAK2 mediated activation of TAK1 complex pathway
REACT_6788
MyD88:Mal cascade initiated on plasma membrane pathway
REACT_8005
Toll Like Receptor TLR1:TLR2 Cascade pathway
REACT_8006
Toll Like Receptor TLR6:TLR2 Cascade pathway
REACT_25120
TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling pathway
REACT_25018
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation pathway
REACT_25354
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation pathway
REACT_25024
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation pathway
REACT_25222
MyD88 dependent cascade initiated on endosome pathway
REACT_9047
Toll Like Receptor 9 (TLR9) Cascade pathway
REACT_27215
MyD88 cascade initiated on plasma membrane pathway
REACT_9027
Toll Like Receptor 10 (TLR10) Cascade pathway
REACT_6894
Toll Like Receptor 4 (TLR4) Cascade pathway
REACT_9061
Toll Like Receptor 5 (TLR5) Cascade pathway
REACT_75776
NOD1/2 Signaling Pathway pathway
REACT_12555
Downstream TCR signaling pathway
REACT_115831
ISG15 antiviral mechanism pathway
REACT_22442
Interleukin-1 signaling pathway
REACT_23787
Regulation of signaling by CBL pathway
REACT_23837
Interleukin-3, 5 and GM-CSF signaling pathway
REACT_118656
Activation of NF-kappaB in B cells pathway
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_160189
Stimuli-sensing channels pathway
REACT_13415
p75NTR recruits signalling complexes pathway
REACT_13696
NF-kB is activated and signals survival pathway
REACT_13643
NRIF signals cell death from the nucleus pathway
REACT_12484
EGFR downregulation pathway
REACT_9417
Signaling by EGFR pathway
REACT_115828
Downregulation of ERBB4 signaling pathway
REACT_115596
Signaling by ERBB4 pathway
REACT_120727
Downregulation of TGF-beta receptor signaling pathway
REACT_120850
TGF-beta receptor signaling activates SMADs pathway
REACT_121111
Downregulation of SMAD2/3:SMAD4 transcriptional activity pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_120726
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) pathway
REACT_115662
Downregulation of ERBB2:ERBB3 signaling pathway
REACT_115755
Signaling by ERBB2 pathway
REACT_118614
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_118780
NOTCH1 Intracellular Domain Regulates Transcription pathway
REACT_160205
NOTCH2 Activation and Transmission of Signal to the Nucleus pathway
REACT_111080
Spry regulation of FGF signaling pathway
REACT_111184
Negative regulation of FGFR signaling pathway
REACT_9470
Signaling by FGFR pathway
REACT_11063
Degradation of beta-catenin by the destruction complex pathway
REACT_25325
AUF1 (hnRNP D0) destabilizes mRNA pathway
REACT_75768
Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) pathway
REACT_75822
Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) pathway
REACT_13464
Regulation of activated PAK-2p34 by proteasome mediated degradation pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_1986
Eukaryotic Translation Termination pathway
REACT_1404
Peptide chain elongation pathway
REACT_1477
Eukaryotic Translation Elongation pathway
REACT_115902
SRP-dependent cotranslational protein targeting to membrane pathway
REACT_24941
Circadian Clock pathway
REACT_9453
Vif-mediated degradation of APOBEC3G pathway
REACT_115893
Membrane binding and targetting of GAG proteins pathway
REACT_9031
Vpu mediated degradation of CD4 pathway
REACT_115852
Signaling by constitutively active EGFR pathway
REACT_9491
Viral mRNA Translation pathway
REACT_160089
Constitutive Signaling by NOTCH1 HD Domain Mutants pathway
REACT_160243
Constitutive Signaling by NOTCH1 PEST Domain Mutants pathway
REACT_160254
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_6361
Late Phase of HIV Life Cycle pathway
REACT_27258
Endosomal Sorting Complex Required For Transport (ESCRT) pathway
REACT_18265
Regulation of the Fanconi anemia pathway pathway
REACT_18410
Fanconi Anemia pathway pathway
REACT_120916
Oxygen-dependent proline hydroxylation of Hypoxia-inducible Factor Alpha pathway
REACT_383
DNA Replication pathway
REACT_120736
Signaling by FGFR in disease pathway
REACT_172581
PCP/CE pathway pathway
REACT_228216
truncated APC mutants destabilize the destruction complex pathway
REACT_85
p53-Dependent G1/S DNA damage checkpoint pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_1208
p53-Independent G1/S DNA damage checkpoint pathway
REACT_228190
Processing-defective Hh variants abrogate ligand secretion pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_163994
FCERI mediated NF-kB activation pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_11061
Signalling by NGF pathway
REACT_228098
AXIN mutants destabilize the destruction complex, activating WNT signaling pathway
REACT_9020
Toll Like Receptor 7/8 (TLR7/8) Cascade pathway
REACT_228143
APC truncation mutants are not K63 polyubiquitinated pathway
REACT_228134
Signaling by Hedgehog pathway
REACT_115871
Signaling by EGFR in Cancer pathway
REACT_228243
AMER1 mutants destabilize the destruction complex pathway
REACT_6167
Influenza Infection pathway
REACT_189085
Disease pathway
REACT_160082
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_75886
Nonsense-Mediated Decay (NMD) pathway
REACT_228096
misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway
REACT_2014
Synthesis of DNA pathway
REACT_228331
Signaling by WNT in cancer pathway
REACT_6828
APC/C-mediated degradation of cell cycle proteins pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_6954
Activation of APC/C and APC/C:Cdc20 mediated degradation of mitotic proteins pathway
REACT_200783
Myoclonic epilepsy of Lafora pathway
REACT_172694
beta-catenin independent WNT signaling pathway
REACT_12526
TCR signaling pathway
REACT_228285
AXIN missense mutants destabilize the destruction complex pathway
REACT_21279
Regulation of mitotic cell cycle pathway
REACT_115676
Antiviral mechanism by IFN-stimulated genes pathway
REACT_169208
Glycogen synthesis pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_11045
Signaling by Wnt pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_160214
Signaling by NOTCH1 in Cancer pathway
REACT_75790
Cytokine Signaling in Immune system pathway
REACT_899
S Phase pathway
REACT_474
Metabolism of carbohydrates pathway
REACT_6802
Innate Immune System pathway
REACT_228196
APC truncation mutants have impaired AXIN binding pathway
REACT_206597
Degradation of GLI2 by the proteasome pathway
REACT_200841
degradation of DVL pathway
REACT_231645
GLI3 is processed to GLI3R by the proteasome pathway
REACT_7980
Toll Like Receptor 2 (TLR2) Cascade pathway
REACT_6966
Toll-Like Receptors Cascades pathway
REACT_200731
deactivation of the beta-catenin transactivating complex pathway
REACT_163936
Fc epsilon receptor (FCERI) signaling pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_115860
Synthesis And Processing Of GAG, GAGPOL Polyproteins pathway
REACT_228261
T41 mutants of beta-catenin aren't phosphorylated pathway
REACT_267605
Degradation of GLI1 by the proteasome pathway
REACT_13537
p75NTR signals via NF-kB pathway
REACT_6152
Influenza Viral RNA Transcription and Replication pathway
REACT_1014
Translation pathway
REACT_160099
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_734
DNA Replication Pre-Initiation pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_1783
G1/S Transition pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_25229
Interferon Signaling pathway
REACT_267634
Hedgehog 'off' state pathway
REACT_21308
MAP kinase activation in TLR cascade pathway
REACT_228314
misspliced GSK3beta mutants stabilize beta-catenin pathway
REACT_163977
Regulation of innate immune responses to cytosolic DNA pathway
REACT_228137
S45 mutants of beta-catenin aren't phosphorylated pathway
REACT_228209
Hh ligand biogenesis disease pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_938
Ubiquitin-dependent degradation of Cyclin D pathway
REACT_228048
deletions in the AMER1 gene destabilize the destruction complex pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_111119
Antigen processing-Cross presentation pathway
REACT_200716
regulation of FZD by ubiquitination pathway
REACT_118721
Signaling by NOTCH2 pathway
REACT_75913
Nucleotide-binding domain, leucine rich repeat containing receptor (NLR) signaling pathways pathway
REACT_199382
Signaling by NOTCH1 pathway
REACT_199384
Activated NOTCH1 Transmits Signal to the Nucleus pathway
REACT_199410
Signaling by NOTCH1 t(7;9)(NOTCH1:M1580_K2555) Translocation Mutant pathway
REACT_17015
Metabolism of proteins pathway
REACT_75774
Adaptive Immune System pathway
REACT_120815
Regulation of Hypoxia-inducible Factor (HIF) by oxygen pathway
REACT_6900
Immune System pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_160301
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_25300
Ion channel transport pathway
REACT_121311
Cellular response to hypoxia pathway
REACT_228159
S33 mutants of beta-catenin aren't phosphorylated pathway
REACT_199405
Signaling by NOTCH1 in Cancer pathway
REACT_199407
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_199406
Signaling by NOTCH1 PEST Domain Mutants in Cancer pathway
REACT_199409
FBXW7 Mutants and NOTCH1 in Cancer pathway
REACT_199408
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_228060
truncations of AMER1 destabilize the destruction complex pathway
REACT_910
M Phase pathway
REACT_169274
Cellular Senescence pathway
REACT_6256
HIV Life Cycle pathway
REACT_228111
Hedgehog ligand biogenesis pathway
REACT_1275
Mitotic Anaphase pathway
REACT_228229
phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway
REACT_200777
TCF dependent signaling in response to WNT pathway
REACT_22232
Signaling by Interleukins pathway
REACT_160248
Signaling by NOTCH1 HD+PEST Domain Mutants in Cancer pathway
REACT_299
Signaling by NOTCH pathway
REACT_2203
G2/M Transition pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_172638
Asymmetric localization of PCP proteins pathway
REACT_1725
M/G1 Transition pathway
REACT_200766
degradation of AXIN pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_13720
Cell death signalling via NRAGE, NRIF and NADE pathway
REACT_24994
Regulation of mRNA stability by proteins that bind AU-rich elements pathway
REACT_228112
deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway
REACT_118859
Signaling by NOTCH1 pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_160133
Signaling by NOTCH1 HD Domain Mutants in Cancer pathway
REACT_228188
RNF mutants show enhanced WNT signaling and proliferation pathway
REACT_228223
TCF7L2 mutants don't bind CTBP pathway
REACT_6185
HIV Infection pathway
REACT_6890
Activated TLR4 signalling pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_169168
Senescence-Associated Secretory Phenotype (SASP) pathway
REACT_75820
Class I MHC mediated antigen processing & presentation pathway
REACT_6145
Influenza Life Cycle pathway
REACT_2254
G1/S DNA Damage Checkpoints pathway
REACT_21391
Mitotic G2-G2/M phases pathway
REACT_188257
Signal Transduction pathway
REACT_111217
Metabolism pathway
REACT_6818
Assembly Of The HIV Virion pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_228279
XAV939 inhibits tankyrase, stabilizing AXIN pathway
REACT_25281
TRIF-mediated TLR3/TLR4 signaling pathway
REACT_6288
Host Interactions of HIV factors pathway
REACT_829
Regulation of DNA replication pathway
REACT_118823
Cytosolic sensors of pathogen-associated DNA pathway
REACT_118773
Signaling by the B Cell Receptor (BCR) pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_231152
Signaling by NOTCH pathway
REACT_6359
Budding and maturation of HIV virion pathway
REACT_118638
Downstream signaling events of B Cell Receptor (BCR) pathway
REACT_13648
Regulation of Apoptosis pathway
REACT_71
Gene Expression pathway
REACT_228251
S37 mutants of beta-catenin aren't phosphorylated pathway
REACT_116125
Disease pathway
REACT_216
DNA Repair pathway
REACT_723
Glucose metabolism pathway
REACT_200833
Glycogen storage diseases pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
REACT_11123
Membrane Trafficking pathway
REACT_1538
Cell Cycle Checkpoints pathway
REACT_150314
Mitotic Metaphase and Anaphase pathway
KEGG
hsa03010
Ribosome pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.700206
RefSeq NM_001135592 NM_001177413 NM_002954
HUGO
OMIM
CCDS CCDS33202
HPRD 01878
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca