InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HAO1

Summary

InnateDB Gene

IDBG-52396.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HAO1

Gene Name

hydroxyacid oxidase (glycolate oxidase) 1

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000101323

Encoded Proteins

IDBP-52398

hydroxyacid oxidase (glycolate oxidase) 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is one of three related genes that have 2-hydroxyacid oxidase activity yet differ in encoded protein amino acid sequence, tissue expression and substrate preference. Subcellular location of the encoded protein is the peroxisome. Specifically, this gene is expressed primarily in liver and pancreas and the encoded protein is most active on glycolate, a two-carbon substrate. The protein is also active on 2-hydroxy fatty acids. The transcript detected at high levels in pancreas may represent an alternatively spliced form or the use of a multiple near-consensus upstream polyadenylation site. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:7882981-7940474

Strand

Reverse strand

Band

p12.3

Transcripts

ENST00000378789

ENSP00000368066

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	1 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003973	(S)-2-hydroxy-acid oxidase activity
GO:0005102	receptor binding
GO:0008891	glycolate oxidase activity
GO:0010181	FMN binding
GO:0015930	glutamate synthase activity
GO:0016491	oxidoreductase activity
GO:0016638	oxidoreductase activity, acting on the CH-NH2 group of donors
GO:0047969	glyoxylate oxidase activity
GO:0052852	very-long-chain-(S)-2-hydroxy-acid oxidase activity
GO:0052853	long-chain-(S)-2-hydroxy-long-chain-acid oxidase activity
GO:0052854	medium-chain-(S)-2-hydroxy-acid oxidase activity

Biological Process

GO:0001561	fatty acid alpha-oxidation
GO:0006537	glutamate biosynthetic process
GO:0006979	response to oxidative stress
GO:0034641	cellular nitrogen compound metabolic process
GO:0044281	small molecule metabolic process
GO:0046296	glycolate catabolic process
GO:0046487	glyoxylate metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005777	peroxisome
GO:0005782	peroxisomal matrix

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000027261

View Gene Order

ENSBTAG00000019811

Not yet available

Pathways

NETPATH

REACTOME

REACT_16925

Glyoxylate metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00630

Glyoxylate and dicarboxylate metabolism pathway

hsa04146

Peroxisome pathway

INOH

PID NCI

Cross-References

SwissProt

Q9UJM8

TrEMBL

A8K058

UniProt Splice Variant

Entrez Gene

54363

UniGene

Hs.193640

RefSeq

NM_017545

HUGO

HGNC:4809

OMIM

605023

CCDS

CCDS13100

HPRD

IMGT

EMBL

AB024079 AF231916 AF244134 AK289423 AK313839 AL021879 AL121739 BC113665 BC113667 CH471133

GenPept

AAF40199 AAF63219 AAI13666 AAI13668 BAA82872 BAF82112 BAG36571 CAB57329 CAC34364 EAX10379 EAX10380

RNA Seq Atlas

54363