InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLIN2

Summary

InnateDB Gene

IDBG-52524.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLIN2

Gene Name

perilipin 2

Synonyms

ADFP; ADRP

Species

Homo sapiens

Ensembl Gene

ENSG00000147872

Encoded Proteins

IDBP-52526

perilipin 2

IDBP-52528

perilipin 2

IDBP-52530

perilipin 2

IDBP-364699

perilipin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:19108375-19149290

Strand

Reverse strand

Band

p22.1

Transcripts

ENST00000276914	ENSP00000276914
ENST00000380465	ENSP00000369832
ENST00000380464	ENSP00000369831
ENST00000434144	ENSP00000403421
ENST00000464326
ENST00000475923
ENST00000472715
ENST00000494753

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0014070	response to organic cyclic compound
GO:0015909	long-chain fatty acid transport
GO:0019915	lipid storage
GO:0042493	response to drug
GO:0044255	cellular lipid metabolic process
GO:0044281	small molecule metabolic process

Cellular Component

GO:0005576	extracellular region
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005783	endoplasmic reticulum
GO:0005811	lipid particle
GO:0005829	cytosol
GO:0005886	plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000028494

View Gene Order

ENSBTAG00000005718

Not yet available

Pathways

NETPATH

REACTOME

REACT_116145

PPARA activates gene expression pathway

REACT_19241

Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) pathway

REACT_22279

Fatty acid, triacylglycerol, and ketone body metabolism pathway

REACT_22258

Metabolism of lipids and lipoproteins pathway

REACT_111217

Metabolism pathway

KEGG

INOH

PID NCI

hif1_tfpathway

HIF-1-alpha transcription factor network

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

RefSeq

NM_001122

HUGO

OMIM

CCDS

CCDS6490

HPRD

IMGT

EMBL

GenPept

RNA Seq Atlas