Version 5.4
Homo sapiens Gene: RTN3
Summary
InnateDB Gene IDBG-52600.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RTN3
Gene Name reticulon 3
Synonyms ASYIP; HAP; NSPL2; NSPLII; RTN3-A1
Species Homo sapiens
Ensembl Gene ENSG00000133318
Encoded Proteins
IDBP-52602
reticulon 3
IDBP-52606
reticulon 3
IDBP-52608
reticulon 3
IDBP-52610
reticulon 3
IDBP-52614
reticulon 3
IDBP-597214
reticulon 3
IDBP-601687
reticulon 3
IDBP-589929
reticulon 3
IDBP-589510
reticulon 3
IDBP-597758
reticulon 3
IDBP-585425
reticulon 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1 (BACE1), and the production of amyloid-beta. An increase in the expression of any reticulon protein substantially reduces the production of amyloid-beta, suggesting that reticulon proteins are negative modulators of BACE1 in cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene, and pseudogenes of this gene are located on chromosomes 4 and 12. [provided by RefSeq, May 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:63681446-63759891
Strand Forward strand
Band q13.1
Transcripts
ENST00000339997 ENSP00000344106
ENST00000356000 ENSP00000348279
ENST00000354497 ENSP00000346492
ENST00000341307 ENSP00000340903
ENST00000338850
ENST00000377819 ENSP00000367050
ENST00000542238 ENSP00000437971
ENST00000538995
ENST00000540798 ENSP00000442733
ENST00000545432 ENSP00000441614
ENST00000543552 ENSP00000442080
ENST00000543123
ENST00000536011 ENSP00000440960
ENST00000537981 ENSP00000440874
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 18 [view]
Protein-Protein 16 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006915 apoptotic process
GO:0006950 response to stress
GO:0016032 viral process
GO:0016192 vesicle-mediated transport
GO:0071786 endoplasmic reticulum tubular network organization
Cellular Component
GO:0000139 Golgi membrane
GO:0005615 extracellular space
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024758
View Gene Order
ENSBTAG00000019204
Not yet available
Cross-References
SwissProt O95197
TrEMBL
UniProt Splice Variant
Entrez Gene 10313
UniGene Hs.743229
RefSeq NM_001265591 NM_001265589 NM_001265590 NM_006054 NM_201428 NM_201429 NM_201430
HUGO HGNC:10469
OMIM 604249
CCDS CCDS58143 CCDS41664 CCDS58141 CCDS58142 CCDS8048 CCDS8049 CCDS8050
HPRD 18516
IMGT
EMBL AB209771 AF059524 AF059525 AF059526 AF059527 AF059528 AF059529 AF119297 AK075412 AK222898 AK295361 AK297529 AP000753 AP006289 AY427821 AY750848 BC000634 BC010556 BC011394 BC022993 BC100822 BC100823 BC105981 BC105982 BC118550 BC118628 BK001681 BK001684 BK001685 CH471076
GenPept AAC99319 AAD20951 AAD26810 AAH00634 AAH10556 AAH11394 AAH22993 AAI00823 AAI00824 AAI05982 AAI05983 AAI18551 AAI18629 AAR02474 AAU81930 BAD93008 BAD96618 BAG52134 BAH12044 BAH12606 DAA01931 DAA01941 DAA01943 EAW74170
RNA Seq Atlas 10313

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca