Version 5.4
Homo sapiens Gene: GATA3
Summary
InnateDB Gene IDBG-52615.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATA3
Gene Name GATA binding protein 3
Synonyms HDR; HDRS
Species Homo sapiens
Ensembl Gene ENSG00000107485
Encoded Proteins
IDBP-52617
GATA binding protein 3
IDBP-52619
GATA binding protein 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation from Orthologs
Summary
PMID 23733962
[Mus musculus] Gata3 is a critical regulator of innate lymphoid cell development from hematopoietic stem cells.
PMID 24419270
[Mus musculus] Gata3 plays a generalized role in innate lymphoid cell (ILC) lineage determination and is critical for the development of gut Rorc+ group 3 ILCs subsets that maintain mucosal barrier homeostasis.
Entrez Gene
Summary This gene encodes a protein which belongs to the GATA family of transcription factors. The protein contains two GATA-type zinc fingers and is an important regulator of T-cell development and plays an important role in endothelial cell biology. Defects in this gene are the cause of hypoparathyroidism with sensorineural deafness and renal dysplasia. [provided by RefSeq, Nov 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:8053604-8075198
Strand Forward strand
Band p14
Transcripts
ENST00000379328 ENSP00000368632
ENST00000346208 ENSP00000341619
ENST00000481743
ENST00000461472
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 68 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 68 [view]
Protein-Protein 25 [view]
Protein-DNA 42 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000976 transcription regulatory region sequence-specific DNA binding
GO:0000977 RNA polymerase II regulatory region sequence-specific DNA binding
GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding
GO:0000987 core promoter proximal region sequence-specific DNA binding
GO:0001046 core promoter sequence-specific DNA binding
GO:0001071 nucleic acid binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001078 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription
GO:0001158 enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005134 interleukin-2 receptor binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046983 protein dimerization activity
GO:0070888 E-box binding
GO:0071837 HMG box domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000902 cell morphogenesis
GO:0001701 in utero embryonic development
GO:0001709 cell fate determination
GO:0001764 neuron migration
GO:0001775 cell activation
GO:0001806 type IV hypersensitivity
GO:0001819 positive regulation of cytokine production
GO:0001822 kidney development
GO:0001823 mesonephros development
GO:0002088 lens development in camera-type eye
GO:0002572 pro-T cell differentiation
GO:0003180 aortic valve morphogenesis
GO:0003215 cardiac right ventricle morphogenesis
GO:0003281 ventricular septum development
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0007165 signal transduction
GO:0007399 nervous system development
GO:0007411 axon guidance
GO:0007596 blood coagulation
GO:0008285 negative regulation of cell proliferation
GO:0008584 male gonad development
GO:0009615 response to virus
GO:0009653 anatomical structure morphogenesis
GO:0009791 post-embryonic development
GO:0009967 positive regulation of signal transduction
GO:0010332 response to gamma radiation
GO:0010595 positive regulation of endothelial cell migration
GO:0010629 negative regulation of gene expression
GO:0010975 regulation of neuron projection development
GO:0014065 phosphatidylinositol 3-kinase signaling
GO:0030182 neuron differentiation
GO:0030217 T cell differentiation
GO:0030218 erythrocyte differentiation
GO:0031929 TOR signaling
GO:0032689 negative regulation of interferon-gamma production
GO:0032703 negative regulation of interleukin-2 production
GO:0032736 positive regulation of interleukin-13 production
GO:0032753 positive regulation of interleukin-4 production
GO:0032754 positive regulation of interleukin-5 production
GO:0033077 T cell differentiation in thymus
GO:0033600 negative regulation of mammary gland epithelial cell proliferation
GO:0035162 embryonic hemopoiesis
GO:0035457 cellular response to interferon-alpha
GO:0035799 ureter maturation
GO:0035898 parathyroid hormone secretion
GO:0042035 regulation of cytokine biosynthetic process
GO:0042421 norepinephrine biosynthetic process
GO:0042472 inner ear morphogenesis
GO:0042493 response to drug
GO:0043370 regulation of CD4-positive, alpha-beta T cell differentiation
GO:0043523 regulation of neuron apoptotic process
GO:0043583 ear development
GO:0043627 response to estrogen
GO:0045061 thymic T cell selection
GO:0045064 T-helper 2 cell differentiation
GO:0045087 innate immune response
GO:0045471 response to ethanol
GO:0045582 positive regulation of T cell differentiation
GO:0045597 positive regulation of cell differentiation
GO:0045599 negative regulation of fat cell differentiation
GO:0045786 negative regulation of cell cycle
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0048485 sympathetic nervous system development
GO:0048538 thymus development
GO:0048568 embryonic organ development
GO:0048589 developmental growth
GO:0048646 anatomical structure formation involved in morphogenesis
GO:0048872 homeostasis of number of cells
GO:0050728 negative regulation of inflammatory response
GO:0050852 T cell receptor signaling pathway
GO:0051569 regulation of histone H3-K4 methylation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060017 parathyroid gland development
GO:0060037 pharyngeal system development
GO:0060065 uterus development
GO:0060231 mesenchymal to epithelial transition
GO:0060374 mast cell differentiation
GO:0060676 ureteric bud formation
GO:0061085 regulation of histone H3-K27 methylation
GO:0061290 canonical Wnt signaling pathway involved in metanephric kidney development
GO:0071345 cellular response to cytokine stimulus
GO:0071353 cellular response to interleukin-4
GO:0071356 cellular response to tumor necrosis factor
GO:0071599 otic vesicle development
GO:0071773 cellular response to BMP stimulus
GO:0072001 renal system development
GO:0072107 positive regulation of ureteric bud formation
GO:0072178 nephric duct morphogenesis
GO:0072179 nephric duct formation
GO:0072182 regulation of nephron tubule epithelial cell differentiation
GO:0072602 interleukin-4 secretion
GO:0072643 interferon-gamma secretion
GO:0072676 lymphocyte migration
GO:2000114 regulation of establishment of cell polarity
GO:2000146 negative regulation of cell motility
GO:2000352 negative regulation of endothelial cell apoptotic process
GO:2000607 negative regulation of cell proliferation involved in mesonephros development
GO:2000611 positive regulation of thyroid hormone generation
GO:2000664 positive regulation of interleukin-5 secretion
GO:2000667 positive regulation of interleukin-13 secretion
GO:2000679 positive regulation of transcription regulatory region DNA binding
GO:2000683 regulation of cellular response to X-ray
GO:2000703 negative regulation of fibroblast growth factor receptor signaling pathway involved in ureteric bud formation
GO:2000734 negative regulation of glial cell-derived neurotrophic factor receptor signaling pathway involved in ureteric bud formation
Cellular Component
GO:0000790 nuclear chromatin
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005730 nucleolus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015619
View Gene Order
ENSBTAG00000017243
Not yet available
Pathways
NETPATH
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
il27pathway
IL27-mediated signaling events
nfat_tfpathway
Calcineurin-regulated NFAT-dependent transcription in lymphocytes
reg_gr_pathway
Glucocorticoid receptor regulatory network
cmyb_pathway
C-MYB transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
notch_pathway
Notch signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.524134 Hs.599561
RefSeq NM_001002295 NM_002051 XM_005252442 XM_005252443
HUGO
OMIM
CCDS CCDS31143 CCDS7083
HPRD 00572
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca